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Experimental animal and human studies demonstrate associations between periodontitis and NAFLD, not yet reported among Hispanics\/Latinos. This study examined periodontitis as a novel risk factor that may contribute to the burden of NAFLD among Hispanics\/Latinos.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data came from 11,914 participants of the Hispanic Community Health Study\/Study of Latinos. Periodontitis was defined as the extent (none,\u00a0&lt;\u00a030%, \u226530%) of periodontal sites with clinical attachment level (CAL) of \u22653\u00a0mm or probing pocket depth (PD) of \u22654\u00a0mm. Elevated serum transaminases indicative of suspected NAFLD were defined as having alanine aminotransferase levels (ALT)\u00a0&gt;\u00a040 IU\/L or aspartate aminotransferase (AST)\u00a0&gt;\u00a037 IU\/L for men and ALT\u00a0&gt;\u00a031 IU\/L or AST\u00a0&gt;\u00a031 IU\/L for women. Survey\u2010logistic regression models estimated prevalence odds ratios (POR) and 95% confidence intervals (CI) for the association between periodontitis and suspected NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall age\u2010standardized percentage of study participants with\u00a0&lt;\u00a030% of sites with CAL \u22653\u00a0mm or PD \u22654\u00a0mm was 53.5% and 58.6%, respectively, while participants with \u226530% sites with CAL \u22653\u00a0mm or PD \u22654\u00a0mm comprised 16% and 5.72%, respectively. The overall age\u2010standardized prevalence (95% CI) of suspected NAFLD was 18.1% (17.1\u201019.0). For the entire cohort, we observed a dose\u2010response (i.e. graded) association between PD \u22654\u00a0mm and the prevalence odds of suspected NAFLD, whereby participants with\u00a0&lt;\u00a030% affected had a crude POR\u00a0=\u00a01.19 (95% CI: 1.03, 1.38) while participants with \u226530% affected had a crude POR\u00a0=\u00a01.39 (95% CI: 1.02, 1.90). These crude estimates were attenuated toward the null and rendered non\u2010significant upon covariate adjustment. No differences were found by Hispanic\/Latino background group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previously reported associations between periodontitis and NAFLD were marginal to null in this study of a diverse group of Hispanics\/Latinos.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0579","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T03:55:18Z","timestamp":1525406118000},"page":"949-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study\/Study of Latinos"],"prefix":"10.1002","volume":"89","author":[{"given":"Aderonke A.","family":"Akinkugbe","sequence":"first","affiliation":[{"name":"Oral Health Services Research Core School of Dentistry Virginia Commonwealth University  Richmond VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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