{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:50:09Z","timestamp":1762102209867,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the contribution of chronic periodontitis (CP) to serum procalcitonin (proCT) levels in chronic migraine (CM) patients in a cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 138 subjects divided into 4 groups based on clinical features of CM and periodontal parameters: systemically and periodontally healthy individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a037), systemically healthy and CP patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), CM and periodontally healthy patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a034), and CM+CP patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a048). Demographic, neurological, clinical data as well as full\u2010mouth periodontal records were obtained. ProCT and high sensitive C\u2010reactive protein (hs\u2010CRP) serum levels were determined from blood samples taken during migraine interictal period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients from the CP+CM group (0.056\u00b10.006\u00a0ng\/mL) had significantly higher serum proCT levels in comparison with the systemically and periodontally healthy group (0.029\u00b10.019\u00a0ng\/mL), CM group (0.041\u00b10.002\u00a0ng\/mL), or CP group (0.034\u00b10.014\u00a0ng\/mL) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). There were no significant differences in hs\u2010CRP between groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.081). Multiple linear regression analysis showed that CP was associated with increased proCT levels in CM patients (R<jats:sup>2\u00a0<\/jats:sup>=\u00a00.293, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CP independently contributes to elevated serum proCT levels in CM patients. These findings suggest that CP could play a role in migraine chronification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0603","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T03:50:57Z","timestamp":1525405857000},"page":"1069-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["High serum procalcitonin levels in patients with periodontitis and chronic migraine"],"prefix":"10.1002","volume":"89","author":[{"given":"Yago","family":"Leira","sequence":"first","affiliation":[{"name":"Periodontology Unit Faculty of Medicine and Odontology University of Santiago de Compostela  Santiago de Compostela Spain"},{"name":"Odontolog\u00eda M\u00e9dico\u2010Quir\u00fargica (OMEQUI) Research Group Health Research Institute of Santiago de Compostela (IDIS)  Santiago de Compostela 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