{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:37:18Z","timestamp":1760920638999,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["EX106\u201010313EC"],"award-info":[{"award-number":["EX106\u201010313EC"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["106\u20102314\u2010B\u2010002\u2010032\u2010MY2"],"award-info":[{"award-number":["106\u20102314\u2010B\u2010002\u2010032\u2010MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Particulate anorganic bovine bone matrix (ABBM) is extensively used for alveolar ridge preservation (ARP). This study evaluates the potential of ABBM\/gelatin cryogel scaffold of regular (250 to 1,000\u00a0\u03bcm) and small (50 to 100\u00a0\u03bcm) particles for ARP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ABBM was either condensed in a gypsum ring to simulate filling of ABBM in a defect or incorporated into a gelatin cryogel scaffold to disperse ABBM. Condensed regular\u2010sized or small\u2010sized ABBM (rABBM or sABBM) (\u00b1 bone morphogenetic protein [BMP]\u20102) were subcutaneously implanted in rats to evaluate biocompatibility and osteogenic potential. Experimental extraction sockets were surgically created on the maxillary ridges of rats and were unfilled (control), filled with rABBM\/gelatin, or sABBM\/gelatin cryogel scaffold. The socket fill and dimensional changes of the ridge were evaluated by microcomputed tomography imaging and histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Condensed sABBM showed acceptable biocompatibility but significantly lower interparticle distance (IPD) and porosity (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) compared with rABBM, whereas rABBM\/gelatin and sABBM\/gelatin cryogel scaffold showed similar IPD and porosity. Osteogenesis took place in rABBM\/gelatin and sABBM\/gelatin\u2010treated extraction sockets showed osteogenesis at 8\u00a0weeks and had increased ridge width and reduced ridge discrepancy compared with the control sites. sABBM\/gelatin scaffold significantly increased socket fill and reduced ridge discrepancy at 4\u00a0weeks, increased ridge width at 8\u00a0weeks, and reduced buccal ridge height resorption at both 4 and 8\u00a0weeks (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Osteoconductivity was suppressed in condensed sABBM, even after adding BMP\u20102. By dispersing sABBM in a gelatin cryogel scaffold, sABBM\/gelatin showed a greater potential in promoting socket fill, reducing buccal ridge atrophy, and providing equivalent ridge stability compared with rABBM\/gelatin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0629","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T03:18:17Z","timestamp":1532402297000},"page":"1221-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preclinical alveolar ridge preservation using small\u2010sized particles of bone replacement graft in combination with a gelatin cryogel scaffold"],"prefix":"10.1002","volume":"89","author":[{"given":"Po\u2010Chun","family":"Chang","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Dentistry School of Dentistry National Taiwan University  Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital  Taipei 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