{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:58:11Z","timestamp":1773057491401,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this split\u2010mouth design pilot study in dogs was to assess microbiologic effects of two topical anti\u2010infective treatment protocols on dental implants subjected to ligature\u2010induced peri\u2010implantitis, without use of systemic antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight adult Beagle dogs each received four dental implants in contralateral, edentulated, mandibular jaw quadrants. After 8 weeks, silk ligatures were installed, to be removed after another 8 weeks. After 6 additional weeks, induced peri\u2010implantitis lesions were subjected to either antimicrobial photodynamic therapy (aPDT) or a topical tetracycline (TTC) hydrochloride (50 mg\/mL) solution. Microbiologic samples were collected from the deepest proximal peri\u2010implantitis site in each jaw quadrant before and after treatment. The samples were analyzed using DNA\u2010DNA hybridization checkerboard technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peri\u2010implantitis induction successfully produced lesions with microbiologic characteristics similar to those found in humans. Overall results showed effective bacterial count reductions for both protocols. aPDT demonstrated major reductions of the red complex, but no statistical differences between groups were observed when adjusted for multiple comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>aPDT and TTC successfully decontaminated infected implant surfaces. Implant decontamination with aPDT appears to be a viable alternative to TTC in the management of peri\u2010implantitis infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0630","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T03:45:15Z","timestamp":1525405515000},"page":"995-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Microbiologic effect of two topical anti\u2010infective treatments on ligature\u2010induced peri\u2010implantitis: A pilot study in dogs"],"prefix":"10.1002","volume":"89","author":[{"given":"Umberto Demoner","family":"Ramos","sequence":"first","affiliation":[{"name":"Department of Buccomaxillofacial Surgery and Periodontology University of S\u00e3o Paulo Ribeirao Preto School of Dentistry Ribeir\u00e3o Preto  S\u00e3o Paulo 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Conde","family":"Vital","sequence":"additional","affiliation":[{"name":"Department of Buccomaxillofacial Surgery and Periodontology University of S\u00e3o Paulo Ribeirao Preto School of Dentistry Ribeir\u00e3o Preto  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio Luis Scombatti","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Buccomaxillofacial Surgery and Periodontology University of S\u00e3o Paulo Ribeirao Preto School of Dentistry Ribeir\u00e3o Preto  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Reis","family":"Messora","sequence":"additional","affiliation":[{"name":"Department of Buccomaxillofacial Surgery and Periodontology University of S\u00e3o Paulo Ribeirao Preto School of Dentistry Ribeir\u00e3o Preto  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela 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