{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:54:51Z","timestamp":1784040891502,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004935","name":"S\u00fcleyman Demirel \u00dcniversitesi","doi-asserted-by":"publisher","award":["4683\u2010DU1\u201016"],"award-info":[{"award-number":["4683\u2010DU1\u201016"]}],"id":[{"id":"10.13039\/501100004935","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Familial Mediterranean fever (FMF) is an inherent autoinflammatory disease and have a high prevalence in Mediterranean countries. The aim of this study was to evaluate salivary levels of oxidative stress parameters in patients with FMF and chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consists of 81 patients with FMF and 85 systemically healthy controls. The test and control groups were classified as chronic periodontitis and periodontally healthy [FMF\u2010periodontitis (n\u00a0=\u00a037); FMF\u2010periodontally healthy (n\u00a0=\u00a044); systemically healthy\u2010periodontitis (n\u00a0=\u00a037); systemically and periodontally healthy (n\u00a0=\u00a048]. Total salivary samples were collected. Clinical periodontal parameters including plaque index, gingival index (GI), probing depth (PD), the percentage of bleeding on probing (BOP%), and clinical attachment level (CAL), were measured. Salivary total antioxidant status (TAS), total oxidant status (TOS), 8\u2010hydroxydeoxyguanosine (8\u2010OHdG), malondialdehyde (MDA), and oxidative stress index (OSI) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FMF\u2010periodontitis group had significantly higher levels of 8\u2010OHdG, MDA, and OSI than that of the FMF\u2010periodontally healthy group. In the FMF\u2010periodontitis group, PD, 8\u2010OHdG, MDA, and OSI levels were significantly higher than in the systemically healthy\u2010periodontitis group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000, respectively). 8\u2010OHdG values were significantly correlated with BOP% and GI, and TOS values were significantly correlated with PD and CAL in the FMF\u2010periodontitis group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the presence of FMF and chronic periodontitis, there were increased salivary levels of oxidative stress. Thus, oxidative stress could be an important inflammatory mechanism in the FMF and chronic periodontitis. Further studies need to clarify the oxidative mechanisms of FMF and chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0638","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T05:29:35Z","timestamp":1526362175000},"page":"1112-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The evaluation of salivary oxidative stress in patients with familial Mediterranean fever and chronic periodontitis"],"prefix":"10.1002","volume":"89","author":[{"given":"G\u00f6zde","family":"Din\u00e7","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry University of S\u00fcleyman Demirel  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Fento\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry University of S\u00fcleyman Demirel  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atalay","family":"Do\u011fru","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Rheumatology University of S\u00fcleyman Demirel  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lter","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine University of S\u00fcleyman Demirel  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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