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We have previously shown that adults with isolated GH deficiency (IGHD) due to a mutation in the GH releasing hormone receptor (GHRHR) gene, have a greater chance of having periodontitis. However, the interaction of GH with periodontal tissues is still unknown, and this population has emerged as a unique model to investigate this issue. Therefore, we evaluated the microbiological and immunological periodontal profiles of such individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen IGHD and 19 controls matched by age, sex, diabetes, and smoking status, were enrolled in this case\u2010control study. Periodontal clinical parameters (probing depth [PD] and clinical attachment loss [AL]) were measured at six sites per tooth. Immune mediators (C\u2010reactive protein, matrix metalloproteinase [MMP]\u20108, MMP\u20109, interleukin [IL]\u20101\u03b1, IL\u20106, IL\u20108, tumor necrosis factor [TNF]\u2010\u03b1, adiponectin, and leptin) were analyzed by enzyme\u2010linked immunosorbent assay (ELISA) in the gingival crevicular fluid (GCF) in four non\u2010adjacent sites for each participant (two with PD \u22643\u00a0mm [shallow sites] and two with PD \u22657\u00a0mm or the worst PD found in the mouth [deep sites]). Bacterial quantification (<jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Treponema denticola<\/jats:italic>, and <jats:italic>Tannerella forsythia<\/jats:italic>) of subgingival biofilm samples collected from these same sites was performed by quantitative real\u2010time polymerase chain reaction (qPCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IGHD individuals presented higher values of PD and AL, and increased levels of CRP, IL\u20108, MMP\u20108, and adiponectin in the GCF. Bacterial quantification did not identify differences between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IGHD alters the local immune response in periodontal pockets leading to greater attachment loss, and GH stands out as an important hormone to be evaluated in the pathogenesis of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0687","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T03:00:45Z","timestamp":1527217245000},"page":"1351-1361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunological and microbiological periodontal profiles in isolated growth hormone deficiency"],"prefix":"10.1002","volume":"89","author":[{"given":"I.M.P.","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Division of Periodontics School of Dentistry University of S\u00e3o Paulo  SP 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