{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:08:10Z","timestamp":1790791690060,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Caspases are key mediators of apoptosis. Caspase\u20108 mediates extrinsic, and caspase\u20109 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase\u2010independent process. Because apoptosis is involved in periodontal disease, this study evaluated caspase\u20108, \u20109, and AIF in periodontal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty periodontally healthy volunteers (Group Healthy), 20 patients with generalized aggressive periodontitis (Group AgP), and 20 patients with generalized chronic periodontitis (Group CP) were included in this study. Levels of caspase\u20108, \u20109, and AIF were evaluated in gingival crevicular fluid (GCF) of all participants via enzyme\u2010linked immunosorbent assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AIF was significantly higher in the AgP (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07) and CP groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) than the Healthy group, and similar to the CP and AgP groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Caspase\u20108 was significantly higher in the CP and Healthy groups than the AgP group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00), and similar between Healthy and CP groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Caspase\u20109 was significantly higher in the AgP group than the Healthy group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), and similar between Healthy and CP groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The mitochondrial\u2010centered intrinsic pathway involving caspase\u20109 and AIF, and the extrinsic pathway involving caspase\u20108 are significant for aggressive periodontitis. The intrinsic pathway involving caspase\u2010independent AIF is also significant for chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0716","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T09:45:10Z","timestamp":1539337510000},"page":"288-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The role of caspase\u20108, caspase\u20109, and apoptosis inducing factor in periodontal disease"],"prefix":"10.1002","volume":"90","author":[{"given":"K\u00fcbra","family":"Aral","sequence":"first","affiliation":[{"name":"Division of Periodontics Malatya Oral and Dental Heath Hospital  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00fcneyt As\u0131m","family":"Aral","sequence":"additional","affiliation":[{"name":"Division of Periodontics Malatya Oral and Dental Heath Hospital  Malatya 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