{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:25:10Z","timestamp":1777307110212,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570987"],"award-info":[{"award-number":["81570987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400523"],"award-info":[{"award-number":["81400523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontal disease is characterized by alveolar bone destruction and degenerative lesions of the periodontal ligament (PDL); it is initiated by bacterial infection of the oral cavity, but the clinical effects are secondary to an aberrant host immune response. Primary hypertension (PH), which causes significant morbidity and mortality worldwide, has also been shown to be an inflammatory disease characterized by aberrant immune cell infiltration and activation. Clinical retrospective studies have shown a link between PH and periodontitis with PH exacerbating periodontitis and vice versa, but the pathophysiologic mechanisms responsible for this remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we investigate the underlying mechanisms behind PH exacerbation of periodontitis by using a bacteria\u2010induced periodontitis model in normotensive and hypertensive (<jats:italic>Nos3<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>) mice treated with or without an Angiotensin II (Ang II) specific receptor 1 (AT1) antagonist, losartan. The histologic analyses including immunohistochemistry, immunofluorescence were carried out. The qRT\u2010PCR and ELISAs were applied for the target gene and protein detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We find that PH worsens bone resorption and PDL destruction in periodontitis and that treatment with losartan, rescues this. We also show that PH increases dendritic cell (DC) and osteoclast (OC) infiltration in periodontitis, which is also dependent on Ang II. Finally, we show that PH augments the pro\u2010inflammatory state in periodontitis infiltrating DCs in an Ang II\u2010dependent manner and use <jats:italic>in vitro<\/jats:italic> studies to show that Ang II directly augments DC Toll\u2010like receptor 4 (TLR4) signaling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our studies show a central role for Ang II as a pro\u2010inflammatory Toll\u2010like receptor mediator in the pathogenesis of PH\u2010exacerbated periodontitis, indicating that Ang II may be a reasonable target in patients with PH and periodontitis comorbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.17-0753","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T01:28:51Z","timestamp":1533173331000},"page":"208-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inhibition of angiotensin II receptor I prevents inflammation and bone loss in periodontitis"],"prefix":"10.1002","volume":"90","author":[{"given":"Jinle","family":"Li","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases Department of Prosthodontics West China Hospital of Stomatology Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Xiao","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases Department of Prosthodontics West China Hospital of Stomatology Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases Department of Prosthodontics West China Hospital of Stomatology Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handong","family":"Ding","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases Department of Prosthodontics West China Hospital of Stomatology Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yue","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases Department of Prosthodontics West China Hospital of Stomatology Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; 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