{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:35:27Z","timestamp":1790174127102,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      is a major periodontopathogen found in patients with chronic periodontitis that can lead to alveolar bone or tooth loss. Interleukin\u20101\u03b2 (IL\u20101\u03b2), a proinflammatory cytokine, is most relevant to the pathogenesis of periodontitis. Catechin is one of the main polyphenol compounds found in green tea and possesses a range of health benefits. This study examined the anti\u2010inflammatory effects of catechin in THP\u20101\u2010derived macrophages infected with\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      as well as its effects on\n                      <jats:italic>P. gingivalis\u2010<\/jats:italic>\n                      induced periodontitis in a mouse model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The cytokine levels and relevant protein expression in THP\u20101 cells were measured using an enzyme\u2010linked immunosorbent assay and Western blot analysis, respectively. An apoptosis\u2010associated speck\u2010like protein containing a caspase recruitment domain (ASC) pyroptosome formation was measured by confocal laser scanning microscopy. Micro\u2010computed tomography was used to determine the level of bone loss induced by a\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      oral infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Catechin attenuated the production of IL\u20101\u03b2 by inhibiting pro\u2010IL\u20101\u03b2 expression via the downregulation of nuclear factor\u2010\u03baB, p38 mitogen\u2010activated protein kinase, and Toll\u2010like receptor signaling. In addition, catechin inhibited the activation of inflammasomes induced by\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      , but did not affect the growth of\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      . Catechin reduced the level of alveolar bone loss in a\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      \u2010induced periodontitis mouse model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Catechin possesses anti\u2010inflammatory properties by reducing the level of IL\u20101\u03b2 production, suggesting that it can potentially be used for the prevention and treatment of periodontal inflammation caused by\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  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