{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:07Z","timestamp":1791288907958,"version":"4.3.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In a previous pilot study, one\u2010time application of anti\u2010<jats:italic>Porphyromonas gingivalis<\/jats:italic> gingipain egg yolk immunoglobulin (IgY) into scaling and root planing (SRP)\u2010treated periodontal pockets showed profound improvement of clinical and bacteriological parameters in patients with chronic periodontitis. The present study aims to evaluate the efficacy of daily use of lozenges fortified with the antibody as an adjunct to non\u2010surgical therapy in patients with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010four patients with periodontitis were divided randomly into a test and a placebo group. The groups were treated by SRP followed by a daily use of lozenges containing either specific IgY against <jats:italic>P. gingivalis<\/jats:italic> gingipains (test) or a sham\u2010immune IgY (placebo). Gingival bleeding index (GBI), probing pocket depth (PD) and quantitation of <jats:italic>P. gingivalis<\/jats:italic> in the gingival pockets were assessed at baseline and 8\u00a0weeks after the initiation of treatment and compared by using Wilcoxon signed rank test, Mann\u2010Whitney <jats:italic>U<\/jats:italic>\u2010test or <jats:italic>t<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed significant improvement of all parameters at 8\u00a0weeks post treatment (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). There was a significant difference in reduction of GBI (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and <jats:italic>P. gingivalis<\/jats:italic> cell counts (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) in the test group compared with the placebo group. The reduction of PD was greater in the test group compared with the placebo group although there was no statistically significant difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The adjunctive use of lozenges containing IgY antibody against gingipains from <jats:italic>P. gingivalis<\/jats:italic> resulted in clinical and microbiological benefits in the treatment for chronic periodontitis. Additional investigations are needed to examine if the IgY brings benefits to case patients who do not receive SRP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0037","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T06:04:05Z","timestamp":1532498645000},"page":"1334-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of lozenges containing egg yolk antibody against <i>Porphyromonas gingivalis<\/i> gingipains as an adjunct to conventional non\u2010surgical therapy in periodontitis patients: A randomized controlled clinical trial"],"prefix":"10.1002","volume":"89","author":[{"given":"Sa V.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Immunology Research in Gifu  Gifu\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh T.H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Periodontology National Hospital of Odonto\u2010Stomatology  Hanoi City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binh C.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Periodontology National Hospital of Odonto\u2010Stomatology  Hanoi City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh T.Q.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Periodontology National Hospital of Odonto\u2010Stomatology  Hanoi City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Umeda","sequence":"additional","affiliation":[{"name":"Immunology Research in Gifu  Gifu\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shofiqur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Immunology Research in Gifu  Gifu\u2010city Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12732"},{"key":"e_1_2_8_3_1","unstructured":"Websites.World Health Organization. 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