{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T21:46:12Z","timestamp":1787175972014,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Spontaneous abortion, or miscarriage, is a complication of pregnancy which can severely affect women both physically and psychologically. We investigated the associations of periodontitis and periodontopathic bacteria with spontaneous abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a matched case\u2010control study in two tertiary hospitals in Khon Kaen, Thailand. Cases were 85 women with spontaneous abortion at\u00a0&lt;20\u00a0weeks of gestation matched to 85 controls on age, gestational age, and hospital. Full\u2010mouth periodontal examinations were performed. Periodontitis was defined as at least one site with probing depth \u22655\u00a0mm and clinical attachment level \u22652\u00a0mm at the same site. Subgingival plaque samples were collected to determine the levels of <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, and <jats:italic>Fusobacterium nucleatum<\/jats:italic> using real time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cases were significantly more likely to have periodontitis (50.6%) than the controls (21.2%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). Conditional logistic regression revealed a crude odds ratio (OR) of 4.1 for the association between periodontitis and spontaneous abortion (95% confidence interval [CI]\u00a0=\u00a01.9\u20138.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). The OR decreased, but was still significant, after controlling for previous miscarriage (OR\u00a0=\u00a03.3, 95% CI\u00a0=\u00a01.4\u20137.8, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). There was no significant association between the levels of periodontopathic bacteria and spontaneous abortion. Increased levels of <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>F. nucleatum<\/jats:italic> were associated with periodontitis in both case and control groups. Association between increased <jats:italic>T. forsythia<\/jats:italic> levels and periodontitis was observed only in the case women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontitis was more common in women with spontaneous abortions as compared with matched controls. Levels of periodontopathic bacteria was not associated with spontaneous abortion in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0174","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T13:15:07Z","timestamp":1540646107000},"page":"381-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between periodontitis and spontaneous abortion: A case\u2010control study"],"prefix":"10.1002","volume":"90","author":[{"given":"Anchana","family":"Chanomethaporn","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anek","family":"Chayasadom","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Khon Kaen University  Khon Kaen 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