{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T20:28:30Z","timestamp":1786825710563,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>ADAMTS (a disintegrin\u2010like and metalloproteinase with thrombospondin) are a family of proteinases that are structurally similar to the family of matrix metalloproteinases with critical roles in damage and repair of the extracellular matrix. Their functions are closely related to inflammation, hypoxia, and vascularization. Our aim was to determine levels of ADAMTS\u20101 in gingival crevicular fluid (GCF) in patients with advanced periodontal diseases and identify their association with hypoxia\u2010inducible factor\u20101alpha (HIF\u20101\u03b1), vascular endothelial growth factor (VEGF\u2010A), and clinical parameters of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study consisted of three groups: healthy individuals (control; n\u00a0=\u00a020), generalized chronic periodontitis (CP; n\u00a0=\u00a021), and generalized aggressive periodontitis (GAgP; n\u00a0=\u00a020). Clinical parameters were measured. Levels of ADAMTS\u20101, VEGF\u2010A, and HIF\u20101\u03b1 in GCF and serum were quantified by enzyme\u2010linked immunosorbent assay (ELISA) and reported as total amounts and concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ADAMTS\u20101 total amount in GCF were significantly higher in patients with CP and GAgP compared with healthy individuals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). HIF\u20101\u03b1 total amount in GCF were also higher in periodontitis groups compared with the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). GCF total VEGF\u2010A content was significantly higher in the GAgP group compared with the CP and the controls (respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). There was a significant correlation between ADAMTS\u20101, VEGF\u2010A, and HIF\u20101\u03b1 levels in the GCF and clinical periodontal parameters (probing depth [PD], bleeding on probing [BOP], and clinical attachment loss (CAL); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ADAMTS\u20101 may play a role in advanced periodontal disease pathogenesis in correlation with tissue hypoxia and vascularization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0195","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T03:23:57Z","timestamp":1556162637000},"page":"1182-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A disintegrin\u2010like and metalloproteinase with thrombospondin\u20101 (ADAMTS\u20101) levels in gingival crevicular fluid correlate with vascular endothelial growth factor\u2010A, hypoxia\u2010inducible factor\u20101\u03b1, and clinical parameters in patients with advanced periodontitis"],"prefix":"10.1002","volume":"90","author":[{"given":"Mahmure Ay\u015fe","family":"Tayman","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eivge","family":"Kurgan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"\u00d6nder","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha","family":"G\u00fcney","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University  Ankara 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