{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:50:07Z","timestamp":1791593407056,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hong Kong Research Grants Council, Hong Kong SAR, China","award":["768713 M"],"award-info":[{"award-number":["768713 M"]}]},{"name":"Hong Kong Research Grants Council, Hong Kong SAR, China","award":["17155216"],"award-info":[{"award-number":["17155216"]}]},{"name":"Modern Dental Laboratory\/The University of Hong Kong"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontal disease closely links to various systemic diseases. This l8\u2010year retrospective cohort study investigated whether poor periodontal condition may increase the risk for onset of systemic comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 488 individual dental folders from 17\u00a0400 dental hospital attendees registered from 1996 to 1998 were randomly selected, and these participants were free of diabetes, cardiovascular disease, chronic obstructive pulmonary disease, cancer, stroke, cognitive impairment, hypertension, and dyslipidemia in the Clinical Management System. The records of periodontal examination and orthopantomogram on the first registration were obtained, and full\u2010mouth bone level (BL) was measured. Onsets of the eight comorbidities concerned above until 2016 were retrieved from the system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The participants with worse periodontal status on their first registration had significantly higher numbers of the eight comorbidities\/mortality during the 18\u2010year follow\u2010ups than their counterparts (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). BL presented as bone loss\/age was independently correlated to the comorbidity profiles in two multivariate models (0 to 1\u00a0versus \u22652; 0 to 2\u00a0versus \u22653) after adjusting for age and sex (odds ratio [OR]\u00a0=\u00a01.87; OR\u00a0=\u00a02.18, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05), highlighting that the individuals with more bone resorption exhibited a greater number of the comorbidities as compared with their counterparts. Moreover, those with onsets of more comorbidities showed worse periodontal conditions according to four parameters employed (community periodontal index, BL, bone loss\/age and number of remaining teeth) (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limitations of this 18\u2010year retrospective cohort study, our findings provide the first evidence that periodontal disease experience to some extent reflects the host susceptibility to onset of common systemic comorbidities. Further studies with larger sample sizes and appropriate adjustment of critical confounders are highly warranted to substantiate the current observation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0224","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T14:06:37Z","timestamp":1539007597000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Periodontal disease increases the risk for onset of systemic comorbidities in dental hospital attendees: An 18\u2010year retrospective cohort study"],"prefix":"10.1002","volume":"90","author":[{"given":"Dan","family":"Zhao","sequence":"first","affiliation":[{"name":"Discipline of Periodontology Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Pelekos","sequence":"additional","affiliation":[{"name":"Discipline of Periodontology Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Hang","family":"Yiu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Jin","sequence":"additional","affiliation":[{"name":"Discipline of Periodontology Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12428"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515602879"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12732"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513490168"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227001"},{"key":"e_1_2_7_8_1","unstructured":"World Health Organization WHO methods and data sources for country\u2010level causes of death 2000\u20132015. 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