{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:17:52Z","timestamp":1779135472551,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09919"],"award-info":[{"award-number":["18K09919"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>People with chronic kidney disease (CKD) may have an increased risk of periodontal disease, but longitudinal evidence is sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This 4\u2010year cohort study assessed the association between CKD and changes in periodontal health status, defined by attachment loss (AL) progression, among older adults. Participants were 388 community\u2010dwelling Japanese adults who were 70 years old at baseline with 7053 teeth. Estimated glomerular filtration rate (eGFR) was calculated by using baseline serum creatinine concentration. AL at six sites for every tooth was recorded at baseline and follow\u2010up examinations. Multilevel logistic regression models estimated the tooth\u2010specific risk of AL progression (\u22651 site exhibiting a \u22653\u00a0mm increase in AL) with baseline CKD (eGFR\u00a0&lt;\u00a060\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>) as the principal exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 27.8% of the study population (108\/388 participants) had CKD. After 4 years, 21.8% of the studied teeth (1537\/7053 teeth) exhibited AL progression. After applying inverse probability weighting and adjusting for potential confounders, including sex, use of devices for interdental cleaning, smoking, diabetes, tooth location, abutment for a removable denture, and highest AL, CKD was associated with significantly higher odds of AL progression (adjusted odds ratio: 1.73; 95% confidence interval: 1.15\u20132.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that CKD increases the risk of periodontal disease progression in older community\u2010dwelling Japanese adults. Additional studies with more complete information, as well as in other geographic areas and age groups, are necessary to further generalize the findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0464","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T03:51:30Z","timestamp":1549511490000},"page":"826-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4\u2010year cohort study"],"prefix":"10.1002","volume":"90","author":[{"given":"Masanori","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Division of Preventive Dentistry Department of Oral Health Science Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"},{"name":"Division of Community Oral Health Development Kyushu Dental University  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George W.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dental Sciences University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misuzu","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Preventive Dentistry Department of Oral Health Science Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Minagawa","sequence":"additional","affiliation":[{"name":"Division of Preventive Dentistry Department of Oral Health Science Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ansai","sequence":"additional","affiliation":[{"name":"Division of 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