{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:52:29Z","timestamp":1778860349703,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"crossref","award":["214S008"],"award-info":[{"award-number":["214S008"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To elucidate molecular signatures of chronic periodontitis (CP) using gingival tissue samples through omics\u2010based whole\u2010genome transcriptomic and whole protein profiling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gingival tissues from 18 CP and 25 controls were analyzed using gene expression microarrays to identify gene expression patterns and the proteins isolated from these samples were subjected to comparative proteomic analysis by liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS). The data from transcriptomics and proteomics were integrated to reveal common shared genes and proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most upregulated genes in CP compared with controls were found as <jats:italic>MZB1, BMS1P20, IGLL1\/IGLL5, TNFRSF17, ALDH1A1, KIAA0125, MMP7, PRL, MGC16025, ADAM11<\/jats:italic>, and the most upregulated proteins in CP compared with controls were BPI, ITGAM, CAP37, PCM1, MMP\u20109, MZB1, UGTT1, PLG, RAB1B, HSP90B1. Functions of the identified genes were involved cell death\/survival, DNA replication, recombination\/repair, gene expression, organismal development, cell\u2010to\u2010cell signaling\/interaction, cellular development, cellular growth\/proliferation, cellular assembly\/organization, cellular function\/maintenance, cellular movement, B\u2010cell development, and identified proteins were involved in protein folding, response to stress, single\u2010organism catabolic process, regulation of peptidase activity, and negative regulation of cell death. The integration and validation analysis of the transcriptomics and proteomics data revealed two common shared genes and proteins, MZB1 and ECH1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Integrative data from transcriptomics and proteomics revealed MZB1 as a potent candidate for chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0477","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T12:20:04Z","timestamp":1547727604000},"page":"663-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis"],"prefix":"10.1002","volume":"90","author":[{"given":"Esra","family":"Guzeldemir\u2010Akcakanat","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begum","family":"Alkan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Sunnetci\u2010Akkoyunlu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busra","family":"Gurel","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry School of Medicine Acibadem Mehmet Ali Ayd\u0131nlar University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Merve","family":"Balta","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahadir","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Akgun","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry School of Medicine Acibadem Mehmet Ali Ayd\u0131nlar University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Busra","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine Kocaeli University  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet 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