{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:23:46Z","timestamp":1768976626660,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Development of autologous and recombinant growth factor\/matrix combination products represent a new emerging trend in regenerative therapeutics and have gained increasing attention as a strategy to optimize tissue regeneration. The aim of the present study was to evaluate the levels of platelet derived growth factor\u2010BB (PDGF\u2010BB) in gingival crevicular fluid (GCF) during early healing period after the regenerative treatment of intrabony defects using beta tricalcium phosphate (\u03b2\u2010TCP) as a bone regeneration material with either platelet rich fibrin (PRF) membrane or collagen membrane (CM) treated with recombinant human PDGF\u2010BB (rhPDGF\u2010BB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients (13 males and 7 females) with chronic periodontitis participated in this prospective, randomized clinical and biochemical study. Each patient was randomly assigned to PRF membrane (group A) or CM incorporated with rhPDGF\u2010BB (group B). GCF samples were obtained on days 3, 7, 14, and 30 for evaluation of PDGF\u2010BB levels and alkaline phosphatase (ALP) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On days 3 and 7 following surgery, mean levels of PDGF\u2010BB at sites treated with PRF membrane or CM incorporated with rhPDGF\u2010BB as a barrier membrane were not significantly different. PDGF\u2010BB levels decreased significantly in samples collected on days 14 and 30 with significant differences between both the groups. ALP levels significantly increased from day 3 to day 30 but there was no difference between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of the study, both PRF membrane and CM incorporated with rhPDGF\u2010BB showed comparable GCF levels of PDGF\u2010BB initially with PRF showing more sustained levels throughout the study period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0496","type":"journal-article","created":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T23:05:10Z","timestamp":1547420710000},"page":"701-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Platelet derived growth factor\u2010BB levels in gingival crevicular fluid of localized intrabony defect sites treated with platelet rich fibrin membrane or collagen membrane containing recombinant human platelet derived growth factor\u2010BB: A randomized clinical and biochemical study"],"prefix":"10.1002","volume":"90","author":[{"given":"Amruta A.","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Periodontics Mahatma Gandhi Mission's Dental College and Hospital  Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashvini M.","family":"Padhye","sequence":"additional","affiliation":[{"name":"Department of Periodontics Mahatma Gandhi Mission's Dental College and Hospital  Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himani S.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College and Hospital  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00317.x"},{"key":"e_1_2_7_3_1","first-page":"44","volume-title":"Glossary of Periodontol 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