{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:46:57Z","timestamp":1787060817266,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The triclosan\u2010containing dentifrices are effective in controlling biofilm formation and maintaining gingival health; however, there is limited information on their effects during the periodontal maintenance phase. Therefore, the aim of this study was to evaluate the clinical effects of a toothpaste containing 0.3% triclosan on the periodontal parameters of subjects that have been treated for peri\u2010implantitis and were enrolled in a regular maintenance program.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Subjects presenting at least one implant with peri\u2010implantitis and received surgical anti\u2010infective therapy were selected. Sixty days post\u2010surgery (baseline), subjects were randomized into two groups: (1) toothpaste containing 0.3% triclosan + 2.0% PVM\/MA copolymer + 1450\u00a0ppm fluoride (test) or (2) toothpaste containing 1450\u00a0ppm fluoride (control), and were instructed to brush with the assigned toothpaste twice\/day for 2 years. They received clinical monitoring at baseline, 3, 6, 12, 18, and 24 months, and professional maintenance every 3 months.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighty\u2010eight subjects with natural teeth were enrolled in the study (Test,\n n<\/jats:italic>\n = 39; Control,\n n<\/jats:italic>\n = 49). The test group showed a greater reduction in the percentage of sites exhibiting bleeding on probing (primary outcome) and lower levels of plaque in comparison with the control group after 24 months (\n P<\/jats:italic>\n \u00a0<\u00a00.05). The mean percentage of sites with probing depth \u22655\u00a0mm was reduced over the course of the study only in the test group (\n P<\/jats:italic>\n \u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A toothpaste containing 0.3% triclosan was more effective than a regular fluoride toothpaste in improving the periodontal clinical condition around natural teeth of periodontally healthy subjects enrolled in a regular maintenance program for 2 years.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jper.18-0501","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T22:55:16Z","timestamp":1569624916000},"page":"596-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a toothpaste containing 0.3% triclosan on periodontal parameters of subjects enrolled in a regular maintenance program: A secondary analysis of a 2\u2010year randomized clinical trial"],"prefix":"10.1002","volume":"91","author":[{"given":"Bernal","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"},{"name":"Colgate\u2010Palmolive Technology Center Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil Awad","family":"Shibli","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Araujo","sequence":"additional","affiliation":[{"name":"School of Dentistry Maringa University Maringa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotinos","family":"Panagakos","sequence":"additional","affiliation":[{"name":"Colgate\u2010Palmolive Technology Center Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Matarazzo","sequence":"additional","affiliation":[{"name":"School of Dentistry Maringa University Maringa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Mairink","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Onuma","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Retamal\u2010Valdes","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo 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