{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:15:07Z","timestamp":1789769707845,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim was to assess the effects of periodontal disease in promoting liver fibrosis in a rat model of ligature\u2010induced periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four Wistar rats were divided into four groups: control (CTRL), experimental periodontitis group at day 7 (PER7), at day 14 (PER14), at day 21 (PER21). Experimental periodontitis was induced by the placement of a silk ligature around mandibular incisors. The following parameters were assessed: gingival index, tooth mobility; liver status, and portal vein caliber by ultrasound examination; bone retraction, bone mineral density (BMD), bone volume\/tissue volume (BV\/TV) by micro\u2010CT analysis; aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT); oxidative stress (malondialdehyde [MDA], reduced glutathione\/oxidative glutathione ratio [GSH\/GSSG]), and matrix metalloproteinase\u20108 (MMP\u20108) levels; and histopathological evaluation of periodontal and liver tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Periodontal parameters showed the development of periodontitis in experimental groups. Micro\u2010CT results indicates an increase of bone retraction and BMD values and a decrease of BV\/TV value in PER groups. Liver fibrosis could not be diagnosed with ultrasound examination in any of the groups. Elevated levels of ASAT and ALAT in PER groups compared with CTRL group were found. MDA have indicated elevated levels and a decrease of GSH\/GSSG ratio in PER group compared with the CTRL group. Levels of MMP\u20108 have indicated high values in PER21 compared with the other groups. Histological analysis of the periodontal and liver tissues sustains the link between periodontal and hepatic injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates a positive correlation between periodontal lesions and liver disease. Periodontitis may be an independent risk factor for liver fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.18-0585","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T12:06:30Z","timestamp":1548677190000},"page":"911-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats"],"prefix":"10.1002","volume":"90","author":[{"given":"Alexandru","family":"Mester","sequence":"first","affiliation":[{"name":"Department of Oral Rehabilitation, Oral Health and Dental Office Management University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Taulescu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Agricultural Sciences and Veterinary Medicine  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos","family":"Apostu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondine","family":"Lucaciu","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, Oral Health and Dental Office Management University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Adriana","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Feldrihan","sequence":"additional","affiliation":[{"name":"Department of Allergology and Immunology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Licarete","sequence":"additional","affiliation":[{"name":"Molecular Biology Centre, Institute for Interdisciplinary Research in Bio\u2010Nano\u2010Sciences Babes\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranka","family":"Ilea","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, Oral Health and Dental Office Management University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra","family":"Piciu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Oltean\u2010Dan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuliu","family":"Scurtu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Agricultural Sciences and Veterinary Medicine  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Berce","sequence":"additional","affiliation":[{"name":"Animal Facility University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Septimiu","family":"Campian","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, Oral Health and Dental Office Management University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.958625"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2012.129"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09R23FM"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.547"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.14.e680"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94416"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312115601122"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572012000200020"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28905-w"},{"key":"e_1_2_9_12_1","first-page":"379","article-title":"Histopathological and clinical expression of periodontal disease related to the systemic inflammatory response","volume":"32","author":"Ionel A","year":"2017","journal-title":"Histol Histopathol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.32.343"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350902794818"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070056"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.03.018"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/302325"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3875"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/24.1.58"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/37.7.1273"},{"key":"e_1_2_9_22_1","first-page":"483","article-title":"Hepatic and systemic effects of rosuvastatin on an experimental model of bile duct ligation in rats","volume":"63","author":"Olteanu D","year":"2012","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.99.2012.1.7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(94)33044-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769709084481"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12329"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010511"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)01043-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300414"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160392"},{"key":"e_1_2_9_32_1","first-page":"e269","article-title":"One or two ligatures inducing periodontitis are sufficient to cause fatty liver","volume":"23","author":"Pessoa L\u2010S","year":"2018","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12459"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.718"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.05.015"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/009127009803801101"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12495"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.02.002"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.04.009"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.12.045"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.18-0585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.18-0585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JPER.18-0585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.18-0585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:35:29Z","timestamp":1760873729000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.18-0585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/JPER.18-0585"],"URL":"https:\/\/doi.org\/10.1002\/jper.18-0585","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,12]]},"assertion":[{"value":"2018-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}