{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:17:04Z","timestamp":1766269024513,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase\u20108 (MMP\u20108) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients with healthy periodontium and investigate the effects of periodontal treatment on the levels of these molecules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GCF samples were collected from periodontally healthy controls (C group, n\u00a0=\u00a020), patients with gingivitis (G group, n\u00a0=\u00a020), and patients with chronic periodontitis (CP group, n\u00a0=\u00a020). Sampling sites were also divided into bleeding (BP) and non\u2010bleeding (NBP) periodontal pocket groups in CP group. Full\u2010mouth clinical periodontal parameters were also recorded. GCF samplings and clinical records were also repeated at 1 and 3 months after treatment for the CP group. SEMA4D, PAD2, and MMP\u20108 levels were determined by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GCF SEMA4D, PAD2, and MMP\u20108 total amounts were similar in CP and G groups (<jats:italic>P<\/jats:italic>\u00a0\u02c3\u00a00.05) but significantly greater than the C group (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.05). The GCF SEMA4D and PAD2 total amounts in the BP group were significantly greater than the NBP group (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.05). GCF MMP\u20108 total amounts were similar in BP and NBP groups (<jats:italic>P<\/jats:italic>\u00a0\u02c3\u00a00.05). The GCF SEMA4D, PAD2, and MMP\u20108 total amounts were significantly reduced at first month after treatment (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.05). There were positive correlations between GCF total amount of SEMA4D and all clinical parameters (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.01) and also between PAD2 and clinical parameters (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.05) except clinical attachment level. There was a positive correlation between GCF total amount of SEMA4D and GCF total amount of MMP\u20108 (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It may be suggested that SEMA4D and PAD2 are related to periodontal disease. Their GCF total amounts may have a diagnostic potential. Additional studies would better clarify their role in periodontal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0608","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T08:44:58Z","timestamp":1556268298000},"page":"973-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase\u20102 levels in periodontal health and disease"],"prefix":"10.1002","volume":"90","author":[{"given":"G\u00f6zde","family":"Veyiso\u011flu","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Baskent University  Ankara Turkey"},{"name":"Department of Periodontology, Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Savran","sequence":"additional","affiliation":[{"name":"Department of 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