{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:48:39Z","timestamp":1780318119299,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["2016\/20020150100004BA"],"award-info":[{"award-number":["2016\/20020150100004BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transient receptor potential vanilloid type\u20101 (TRPV1) is expressed in oral tissues cells and its activity can be regulated by inflammation products and anandamide. The aim of the present study was to evaluate the effects of blocking TRPV1 or specific cannabinoid receptors 1 (CB1r) and 2 (CB2r) on periodontal status of rats subjected to experimental periodontitis (EP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male rats were distributed in groups 1) control, 2) lipopolysaccharide\u2010induced EP (LPS), and 3) LPS plus capsazepine (Capz, TRPV1 antagonist) application (LPS+Capz). EP was induced by injections of LPS (1 mg\/mL) around first molars and treatment was performed with Capz (2 \u00b5g\/mL) applied locally during 6 weeks. Additional experiment was performed by applying CB1r and CB2r antagonists (AM251 and AM630) to rats with EP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Capz prevented alveolar bone loss (ABL) on the external crests and in the interradicular bone of the first molars (periodontal space height: LPS, 270.7 \u00b1 33.5\u00b5m versus LPS+Capz, 216.4 \u00b1 19.9 \u00b5m; <jats:italic>P<\/jats:italic> &lt;0.01). Inflammatory mediators, like tumor necrosis factor\u2010alpha and prostaglandin E<jats:sub>2<\/jats:sub>, increased by LPS\u2010induced EP, were diminished in gingival tissue of rats treated with Capz. In contrast, application of AM251 and AM630 exacerbated ABL and gingival inflammatory mediators, increased by LPS, altering also biomechanical properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TRPV1 blockade attenuates periodontal impairment in EP rats, since it reduces local inflammation, unlike CB1r and CB2r blockade. This work lays the foundation for developing therapeutics in humans based on the pharmacological manipulation of these receptors to treat periodontal disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.18-0766","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T09:44:27Z","timestamp":1557567867000},"page":"1325-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A new target to ameliorate the damage of periodontal disease: The role of transient receptor potential vanilloid type\u20101 in contrast to that of specific cannabinoid receptors in rats"],"prefix":"10.1002","volume":"90","author":[{"given":"C\u00e9sar A.","family":"Ossola","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Dentistry University of Buenos Aires  Buenos Aires Argentina"},{"name":"National Council of Scientific and Technical Research (CONICET)  Buenos Aires 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