{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:19:05Z","timestamp":1773073145111,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and\/or enamel matrix derivative (EMD) for the treatment of dehiscence\u2010type recession defects in minipigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight healthy, male, young BR\u20101 minipigs, with no periodontal disease were treated. Bilateral dehiscence\u2010type defects were surgically created on the buccal of the mandibular premolars (PI and PII). After 30 days, the defects were randomly assigned to four groups: coronally advanced flap (CAF); CAF + CM; CAF + EMD; and CAF + CM + EMD (split\u2010mouth design). The evaluated parameters (mm): total defect length; new cementum (NC); new bone (NB); gingival margin position; total epithelium length; epithelium on the root; connective tissue adaptation; and soft tissue thickness (STT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EMD\u2010treated groups showed a superior length of NC [4.13\u00a0\u00b1\u00a01.22 (CAF\u00a0+ EMD); 3.95\u00a0\u00b1\u00a01.11 (CAF + CM + EMD); 2.94\u00a0\u00b1\u00a00.77 (CAF + CM); 2.72\u00a0\u00b1\u00a00.81 (CAF), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02] and NB [3.21\u00a0\u00b1\u00a00.68 (CAF + CM + EMD); 3.01\u00a0\u00b1\u00a00.56 (CAF + EMD); 2.15\u00a0\u00b1\u00a00.47 (CAF + CM); 2.29\u00a0\u00b1\u00a00.82 (CAF), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005]. The CAF and CAF + CM groups showed a superior epithelial length when compared to EMD\u2010treated groups after 3 months. A superior STT was observed for CAF + CM + EMD group (1.5\u00a0\u00b1\u00a00.33) when compared with the other groups [1.09\u00a0\u00b1\u00a00.26 (CAF + EMD); 1.04\u00a0\u00b1\u00a00.34 (CAF + CM); and 1.14\u00a0\u00b1\u00a00.29 (CAF), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion(s)<\/jats:title><jats:p>The results of the present study indicate that EMD application, irrespective of the combination with CM, may improve the periodontal regeneration of dehiscence\u2010type defects in this animal model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0107","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T06:52:46Z","timestamp":1576219966000},"page":"967-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of dehiscence\u2010type defects with collagen matrix and\/or enamel matrix derivative: Histomorphometric study in minipigs"],"prefix":"10.1002","volume":"91","author":[{"given":"Isabela Lima","family":"Fran\u00e7a\u2010Grohmann","sequence":"first","affiliation":[{"name":"Division of Periodontics Piracicaba Dental School\/State University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-9366","authenticated-orcid":false,"given":"Jo\u00e3o Paulo Menck","family":"Sangiorgio","sequence":"additional","affiliation":[{"name":"Division of Periodontics Piracicaba Dental School\/State University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3073-039X","authenticated-orcid":false,"given":"Manuela Rocha","family":"Bueno","sequence":"additional","affiliation":[{"name":"Division of Periodontics Piracicaba Dental School\/State University of Campinas (UNICAMP)  Piracicaba 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