{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:11:44Z","timestamp":1780697504493,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While leukocytosis is a common feature of severe periodontitis, a smaller amount of evidence has been produced on erythrocytes counts in periodontitis, suggesting a possible tendency to anemia. The aim of this study was to investigate the associations between periodontitis and circulating leukocytes, erythrocytes, and platelets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 471 patients with periodontitis (including aggressive periodontitis [AgP], and chronic periodontitis [CP]) and periodontal health. A separate sample of 333 patients from a previous study (127 AgP and 206 periodontally healthy) was used as replication. Periodontal clinical data were collected and a blood sample was obtained from each participant for hematological analysis of leukocytes, erythrocytes and platelets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusted linear regression analyses revealed associations between periodontitis and total leukocytes counts (<jats:italic>p<\/jats:italic> &lt; 0.001), neutrophil counts (<jats:italic>P<\/jats:italic> &lt;0.001) and hematocrit (HCT) levels (<jats:italic>P<\/jats:italic> = 0.045). Sub\u2010analysis revealed no statistically significant differences between AgP and CP. Disease severity was correlated with total leukocyte and neutrophil counts and HCT (<jats:italic>P<\/jats:italic> &lt;0.001, <jats:italic>P<\/jats:italic> &lt;0.001 and <jats:italic>P<\/jats:italic> = 0.004, respectively). In the replication sample, adjusted linear regression analysis revealed associations between periodontitis and decreased hemoglobin (HB) (<jats:italic>P<\/jats:italic> = 0.009), mean corpuscular hemoglobin (MCH) (<jats:italic>P<\/jats:italic> = 0.023), and MCH concentration (<jats:italic>P<\/jats:italic> &lt;0.001). A subset of patients included in these studies (14% to 15.7% of periodontitis versus 8.4% to 10.2% of healthy, respectively, in the two cohorts) were anemic based on the World Health Organization criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This paper, reporting results of periodontal examination and blood sampling in over 800 patients, suggest that not just leukocytosis but also tendency to \u201canemia of inflammation\u201d are typical features of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0124","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T04:16:29Z","timestamp":1558584989000},"page":"1252-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Anemia of inflammation associated with periodontitis: Analysis of two clinical studies"],"prefix":"10.1002","volume":"90","author":[{"given":"Luigi","family":"Nibali","sequence":"first","affiliation":[{"name":"Centre for Oral Immunobiology and Regenerative Medicine and Centre for Oral Clinical Research Institute of Dentistry Queen Mary University London (QMUL)  London United Kingdom"},{"name":"Centre for Host\u2010Microbiome Interactions Dental Institute King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulpee","family":"Darbar","sequence":"additional","affiliation":[{"name":"University College Hospitals NHS Trust (UCLH) Eastman Dental Hospital  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanasak","family":"Rakmanee","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Thammasat University  Pathum Thani Phra Nakhon Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Donos","sequence":"additional","affiliation":[{"name":"Centre for Oral Immunobiology and Regenerative Medicine and Centre for Oral Clinical Research Institute of Dentistry Queen Mary University London (QMUL)  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340019"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2014.04.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgpopen18X101597"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028010930.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100079"},{"key":"e_1_2_8_8_1","first-page":"195","article-title":"Effect of scaling and root planing on erythrocyte count, hemoglobin and hematocrit in patients with chronic periodontal disease","volume":"86","author":"Malhotra R","year":"2012","journal-title":"J Dent Hyg"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12154"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.10.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21673"},{"key":"e_1_2_8_13_1","unstructured":"Centers for Disease Control and Prevention.Preventing emerging infectious diseases: Addressing the problem of antimicrobial resistance. 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