{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:39:59Z","timestamp":1772491199955,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to histologically evaluate and compare vital bone formation, residual graft particles, and fraction of connective tissue (CT)\/other tissues between three different time points at 2\u2010month intervals after alveolar ridge preservation with a cancellous allograft and dense\u2012polytetrafluoroethylene (d\u2010PTFE) membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ridge preservation with a cancellous allograft and d\u2010PTFE membrane was performed at 49 extraction sockets (one per patient). Volunteers were assigned to implant placement at three different time points of 2, 4, and 6 months, at which time core biopsies were obtained. Histomorphometric analysis was performed to determine the percentages of vital bone, residual graft particles, and connective tissue\/other non\u2010bone components, and subjected to statistical analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant difference in the amount of vital bone at every time point from 28.31% to 40.87% to 64.11% (at 2\u2010, 4\u2010, and 6\u2010month groups, respectively) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The percentage of residual graft particles ranged from 44.57% to 36.16% to 14.86%, showing statistical significance from 4 to 6 months (21.29%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and 2 to 6 months (29.71%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), while there were no significant differences for the amount of CT\/other tissue among the different time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provided the first histologic comparison of alveolar ridge preservation using a cancellous allograft and d\u2010PTFE membrane at three different time points. Extraction sockets that healed for 6 months produced the highest amount of vital bone in combination with the least percentage of residual graft particles, while similar results were observed for the fraction of CT\/other tissues between the three time points.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0142","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T02:03:08Z","timestamp":1564970588000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Time analysis of alveolar ridge preservation using a combination of mineralized bone\u2010plug and dense\u2010polytetrafluoroethylene membrane: A histomorphometric study"],"prefix":"10.1002","volume":"91","author":[{"given":"Shih\u2010Cheng","family":"Wen","sequence":"first","affiliation":[{"name":"Taipei Medical University  Taipei Taiwan"},{"name":"Private practice  Taipei Taiwan"},{"name":"Ching Kuo Institute of Management and Health  Keelung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-6577","authenticated-orcid":false,"given":"Shayan","family":"Barootchi","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Xia","family":"Huang","sequence":"additional","affiliation":[{"name":"Periodontics Department Xiamen Stomatological Hospital  Xiamen P. 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