{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:56:04Z","timestamp":1782536164598,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bisphosphonate (BP)\u2010related osteonecrosis of the jaw (BRONJ) and dental implant failure are two negative side effects of chronic aminoBP treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven ovariectomized (OVX) ewes and four ewes subjected to sham surgery (SHAM) were treated as follows: OVX (<jats:italic>n<\/jats:italic>\u00a0=\u00a05): OVX plus saline solution; zoledronic acid\u2010treated group (ZOL) (<jats:italic>n<\/jats:italic>\u00a0=\u00a06): OVX plus ZOL; SHAM (<jats:italic>n<\/jats:italic>\u00a0=\u00a04): SHAM plus saline solution. Extraction of the first upper molar was performed at 1 year, dental implant placement at 2 years, and sacrifice at 28 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Implants remained in place in SHAM and OVX ewes but were lost in all ZOL ewes. ZOL sheep (2\/6) showed inflammation and necrotic bone at mandibular region. No differences in serum calcium (Ca), inorganic phosphate (Pi) or 25\u2010hydroxyvitamin D were observed, whereas bone alkaline phosphatase levels decreased in the three studied groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The significantly lowest levels of carboxy\u2010terminal telopeptide of type I collagen were observed in ZOL (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and showed no differences between SHAM and OVX. OVX showed the lowest and ZOL the highest Ca and Pi contents in femur and maxilla (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Bone volume (BV\/TV%) and iliac crest were similar at baseline and at month 4. At the end of the study, BV\/TV%, proximal femur and hemi\u2010mandible bone mineral content and bone mineral density, and trabeculae number were similar in SHAM and ZOL, and lower in OVX (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All ZOL\u2010treated ewes on a schedule similar to that used in cancer patients showed extensive suppression of bone remodeling and implant failure. Some of the ZOL ewes developed BRONJ.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0213","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T04:44:28Z","timestamp":1574397868000},"page":"628-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Aminobisphosphonate\u2010treated ewes as a model of osteonecrosis of the jaw and of dental implant failure"],"prefix":"10.1002","volume":"91","author":[{"given":"Mario R.","family":"Davison","sequence":"first","affiliation":[{"name":"School of Dentistry Rio Negro National University  R\u00edo Negro Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Lyardet","sequence":"additional","affiliation":[{"name":"School of Dentistry Rio Negro National University  R\u00edo Negro Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Preliasco","sequence":"additional","affiliation":[{"name":"School of Dentistry Rio Negro National University  R\u00edo Negro Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Yaful","sequence":"additional","affiliation":[{"name":"Veterinary Sciences Rio Negro National University  R\u00edo Negro Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla","family":"Torres","sequence":"additional","affiliation":[{"name":"Veterinary Sciences Rio Negro National University  R\u00edo Negro Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina S.","family":"Bonanno","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Laboratory Immunology Genetic and Metabolism Institute (INIGEM) School of Pharmacy and Biochemistry, Clinical Hospital \u201cJos\u00e9 de San Mart\u00edn\u201d National Council for Scientific and Technologic Research (CONICET)\/Buenos Aires University (UBA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretel G.","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Laboratory Immunology Genetic and Metabolism Institute (INIGEM) School of Pharmacy and Biochemistry, Clinical Hospital \u201cJos\u00e9 de San Mart\u00edn\u201d National Council for Scientific and Technologic Research (CONICET)\/Buenos Aires University (UBA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana N.","family":"Zeni","sequence":"additional","affiliation":[{"name":"Metabolic Bone Diseases Laboratory Immunology Genetic and Metabolism Institute (INIGEM) School of Pharmacy and Biochemistry, Clinical Hospital \u201cJos\u00e9 de San Mart\u00edn\u201d National Council for Scientific and Technologic Research (CONICET)\/Buenos Aires University (UBA)  Buenos Aires 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