{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:32Z","timestamp":1786978112193,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The inflammasome modulates the release of key proinflammatory cytokines associated with periodontal disease pathogenesis. The aim of this study was to evaluate the expression of proteins that regulate the inflammasome, namely pyrin domain\u2010only proteins (POPs), caspase activation recruitment domain (CARD)\u2010only proteins, and tripartite motif\u2010containing (TRIM) proteins, in periodontal diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 68 participants (34 males and 34 females) were divided into four groups, including periodontal health (H), gingivitis (G), chronic periodontitis (CP), and aggressive periodontitis (AgP) based on clinical parameters. Gingival tissue samples were obtained from all participants for reverse transcription polymerase chain reaction (RT\u2010PCR)\u2010based gene expression analyses of molecules that regulate the inflammasome, including apoptosis\u2010associated speck\u2010like protein (ASC) containing CARD, caspase\u20101, interleukin\u20101\u03b2 (IL\u20101\u03b2), interleukin\u201018 (IL\u201018), nucleotide\u2010binding domain, leucine rich family (NLR) pyrin domain containing 3 (NLRP3), NLR family pyrin domain containing 2 (NLRP2), AIM2 (absent in melanoma 2), POP1, POP2, CARD16, CARD18, TRIM16, and TRIM20 by RT\u2010PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NLRP3 and IL\u20101\u03b2 were upregulated in the G, CP, and AgP groups compared with group H (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). AIM2 was downregulated in the CP group compared with the H, G, and AgP groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). TRIM20, TRIM16, and CARD18 were downregulated in the G, CP, and AgP groups compared with the H group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). POP1 and POP2 were downregulated in the CP and AgP, and AgP and G groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Active periodontal disease may result in downregulation of inflammasome regulators that may increase the activity of NLRP3 and IL\u20101\u03b2 in periodontal disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.19-0222","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T22:21:10Z","timestamp":1569536470000},"page":"606-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Differential expression of inflammasome regulatory transcripts in periodontal disease"],"prefix":"10.1002","volume":"91","author":[{"given":"K\u00fcbra","family":"Aral","sequence":"first","affiliation":[{"name":"Oral Biology, School of Dentistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eynar","family":"Berdeli","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Roy","family":"Cooper","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Robert","family":"Milward","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Kapila","sequence":"additional","affiliation":[{"name":"The School of Dentistry University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyza","family":"Karadede \u00dcnal","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00fcneyt As\u0131m","family":"Aral","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afig","family":"Berdeli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Molecular Medicine Laboratory Ege University  Izmir 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