{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:39:31Z","timestamp":1765805971294,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased levels of periodontal pathogens disrupt the homeostasis between the host and its microbiota and increase susceptibility to periodontal diseases. Periodontitis increases the serum concentration of mannose\u2010binding lectin (MBL), which exacerbates local inflammatory processes. In animal studies, sirtuin 1 (SIRT1) was associated with protection against inflammation. This study analyzed the influence of non\u2010surgical periodontal treatment on serum levels of MBL and SIRT1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with periodontitis and 38 periodontally healthy individuals (aged 45 to 79 years) were included. Periodontitis patients received scaling and root planing using machine driven and hand instruments. Clinical parameters, inflammatory biomarkers, MBL, and SIRT1 levels were measured at baseline and at post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all patients, an inverse correlation was observed between serum concentrations of MBL and SIRT1 (r\u00a0=\u00a0\u20100.30; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). Periodontal treatment reduced serum concentrations of MBL (1,099.35\u00a0\u00b1\u00a0916.59 to 861.42\u00a0\u00b1\u00a0724.82\u00a0ng\/mL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and C\u2010reactive protein (6.05\u00a0\u00b1\u00a08.99 to 2.49\u00a0\u00b1\u00a02.89\u00a0mg\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). By contrast, SIRT1 serum levels increased (1.06\u00a0\u00b1\u00a01.03 to 1.66\u00a0\u00b1\u00a01.64\u00a0ng\/mL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) following periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontal treatment was associated with decreased serum concentrations of MBL and CRP and increased serum levels of SIRT1. Prospective studies are needed to assess the impact of these biomarkers on pathophysiology of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0236","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:09:19Z","timestamp":1574294959000},"page":"900-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Influence of the treatment of periodontal disease in serum concentration of sirtuin 1 and mannose\u2010binding lectin"],"prefix":"10.1002","volume":"91","author":[{"given":"P\u00e9rola Michelle Vasconcelos","family":"Carib\u00e9","sequence":"first","affiliation":[{"name":"Clinical Department, Heart Institute (InCor) University of S\u00e3o Paulo Medical School  Sao Paulo Brazil"},{"name":"Division of Periodontology Stomatology Department, Dental School University of Sao Paulo, Sao Paulo Brazil PhD thesis of the Heart Institute (InCor) University of S\u00e3o Paulo 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