{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:07:52Z","timestamp":1787242072613,"version":"build-2736575974"},"reference-count":100,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This systematic review endeavored to investigate the effect of soft tissue phenotype modification therapy (PhMT\u2010s) at sites with a tooth or an implant supported fixed dental prosthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted by two independent examiners to identify relevant studies reporting differences in clinical, esthetic, or radiographic outcomes of interest between sites underwent PhMT\u2010s and sites that remained untreated. Risk of bias assessment was calculated for all included studies. Meta\u2010analyses involving endpoints of interest were performed when feasible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No controlled studies pertaining to tooth sites were identified. A total of six articles reporting on the outcomes of buccal soft tissue phenotype modification around implants were selected, of which, five were included in the meta\u2010analyses. Quantitative analyses showed a weighted mean difference (WMD) of 0.98\u00a0mm (95% CI = 0.25 to 1.72\u00a0mm,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.009) for change of tissue thickness; a WMD of \u22124.87% (95% CI = \u221234.27 to 24.53%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.75) for bleeding on probing (BOP); a WMD of 0.36\u00a0mm (95% CI = 0.12 to 0.59\u00a0mm,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003) for mucosal recession (MR); a WMD of 0.13\u00a0mm (95% CI = \u22120.11 to 0.36\u00a0mm,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.30 for probing depth (PD); a WMD of 1.08 (95% CI = \u22120.39 to 2.55,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.15) for pink esthetic score (PES), and a WMD of 0.40\u00a0mm (95% CI = \u22120.34 to 1.14\u00a0mm,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.28) for marginal bone loss (MBL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical modification of peri\u2010implant soft tissue phenotype via PhMT\u2010s may decrease the amount of MR. Future clinical trials are needed to warrant the clinical benefits of modifying soft tissue phenotype around tooth\u2010supported restorations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.19-0310","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T11:57:30Z","timestamp":1572523050000},"page":"339-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The significance of surgically modifying soft tissue phenotype around fixed dental prostheses: An American Academy of Periodontology best evidence review"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-9994","authenticated-orcid":false,"given":"Guo\u2010Hao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California San Francisco  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald A.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dental Sciences School of Dentistry University of California San Francisco  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Kapila","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California San Francisco  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Velasquez","sequence":"additional","affiliation":[{"name":"Graduate Periodontics Department of Periodontics &amp; Oral Medicine School of Dentistry University of Michigan  Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Y.K.","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry School of Dentistry Loma Linda University  Loma Linda CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Tahir","sequence":"additional","affiliation":[{"name":"University of California San Francisco Library  CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-0201","authenticated-orcid":false,"given":"Gustavo","family":"Avila\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Periodontics College of Dentistry University of Iowa  Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California San Francisco  San Francisco CA"},{"name":"Private Practice  Cupertino CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0733"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01186.x"},{"key":"e_1_2_8_4_1","first-page":"85","article-title":"Effect of different prosthetic abutments on peri\u2010implant soft tissue. 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