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Living cellular constructs based on fibroblasts, keratinocytes alone or in combination have been developed and used as alternatives to autogenous soft tissue grafts in keratinized tissue augmentation and in root coverage procedures. Their promising advantages include reduced patient morbidity, unlimited graft availability, and comparable esthetics. This manuscript reviews soft tissue augmentation and root coverage procedures using bioengineered living cellular therapy and highlights their expected clinical, esthetic, and patient\u2010related outcomes.<\/jats:p>","DOI":"10.1002\/jper.19-0353","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T09:51:16Z","timestamp":1567072276000},"page":"155-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Living cell\u2010based regenerative medicine technologies for periodontal soft tissue augmentation"],"prefix":"10.1002","volume":"91","author":[{"given":"Michael K.","family":"McGuire","sequence":"first","affiliation":[{"name":"Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry  Ann Arbor MI USA"},{"name":"Private practice  Houston TX USA"},{"name":"Department of Periodontics University of Texas Dental Branch Houston and Health Science Center  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