{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:46:02Z","timestamp":1767339962388,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,29]],"date-time":"2019-12-29T00:00:00Z","timestamp":1577577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individuals with altered passive eruption (APE) are assumed to be more susceptible to periodontal diseases. To date, this hypothesis has not been sufficiently supported by scientific evidence. The aim of this study, using an experimental gingivitis model, was to examine the development and resolution of gingival inflammation in patients with APE when compared to patients with normal gingival anatomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A localized experimental gingivitis was induced in 9 patients with APE (test group) and 9 patients without APE (control group) in the maxillary right quadrant. After 21 days, patients were instructed to resume proper home oral hygiene procedures. At baseline (day 0) and at days 7, 14, 21, 28, 35, and 42, plaque index (PlI), gingival index (GI), and gingival crevicular fluid volume (GCF) were evaluated for teeth 6 (canine), 7 (lateral incisor) and 8 (central incisor) of test and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the experimental gingivitis phase (days 0 to 21), the rate of change in gingival inflammation (GI) was dramatically different between the APE test group and the control group. On day 21, at the time of maximum plaque accumulation, the GI of the APE test group was a 109% greater than the GI of the test group (<jats:italic>P<\/jats:italic> \u2264 0.001) despite similar plaque levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.436). During the resolution of inflammation phase (days 22 to 42), the APE test group continued to exhibit statistically higher GI scores than the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the presence of similar amounts of plaque deposits and plaque accumulation rates, APE patients exhibited differences in the development and resolution of plaque\u2010induced gingival inflammation when compared to controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0443","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T02:26:03Z","timestamp":1576203963000},"page":"938-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Experimental gingivitis in patients with and without altered passive eruption"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-638X","authenticated-orcid":false,"given":"Rustam","family":"Aghazada","sequence":"first","affiliation":[{"name":"Section of Periodontics Department of Oral and Maxillofacial Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Marini","sequence":"additional","affiliation":[{"name":"Section of Periodontics Department of Oral and Maxillofacial Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blerina","family":"Zeza","sequence":"additional","affiliation":[{"name":"Division of Periodontology Department of Dentistry Albanian University  Tirana Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Trezza","sequence":"additional","affiliation":[{"name":"Section of Periodontics Department of Oral and Maxillofacial Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarita","family":"Vestri","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Division of Periodontology College of Dentistry The Ohio State University  Columbus OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pilloni","sequence":"additional","affiliation":[{"name":"Section of Periodontics Department of Oral and Maxillofacial Sciences \u201cSapienza\u201d University of Rome  Rome Italy"},{"name":"Division of Periodontology College of Dentistry The Ohio State University  Columbus OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"214","article-title":"Active and passive continuous eruption of teeth","volume":"13","author":"Gottlieb B","year":"1933","journal-title":"J Den Res"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.16.e100"},{"key":"e_1_2_7_4_1","first-page":"292","article-title":"Clinical definition of altered passive eruption","volume":"147","author":"Volchansky A","year":"1979","journal-title":"Brit Dent J"},{"key":"e_1_2_7_5_1","first-page":"24","article-title":"Diagnosis and classification of delayed passive eruption of the dentogingival junction in the adults","volume":"3","author":"Coslet JO","year":"1977","journal-title":"Alpha Omegan"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01940.x"},{"key":"e_1_2_7_7_1","first-page":"291","article-title":"Delayed passive eruption. 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