{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:40:50Z","timestamp":1768873250151,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare the effects of full\u2010mouth disinfection (FMD) and full\u2010mouth ultrasonic debridement (FMUD) on clinical, microbiological and biochemical parameters with conventional quadrant\u2010wise scaling and root planning (Q\u2010SRP) in severe chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present prospective randomized controlled clinical trial with three parallel arms (#NCT04038801), 60 chronic periodontitis patients were randomly assigned to three study groups by a consecutive number in ascending order: FMD (n\u00a0=\u00a020), FMUD (n\u00a0=\u00a020), and Q\u2010SRP (n\u00a0=\u00a020). All measurements and treatments were performed by the same investigator. At baseline, gingival crevicular fluid (GCF) and subgingival plaque were collected and clinical periodontal parameters were recorded. Ultrasonic debridement was completed within 24\u00a0hours in FMD and FMUD groups. Chlorhexidine gluconate was used for FMD. Q\u2010SRP was performed by hand instruments per quadrant at 1\u2010week\u2010intervals. Clinical measurements and sampling were repeated at 1, 3, and 6 months after treatment. Real\u2010time PCR was used for quantitative analysis of <jats:italic>Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum<\/jats:italic>, and total bacteria count. GCF Calprotectin, osteocalcin, and N\u2010telopeptide of type I collagen (NTx) levels were analyzed by ELISA. The changes of GCF biomarker levels after treatment between groups were the primary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No harm was observed. All treatment strategies resulted in significant improvements in all clinical parameters (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), with no significant differences between study groups at all time\u2010points (<jats:italic>P<\/jats:italic> \u02c3 0.05). <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> was significantly decreased in FMD compared to FMUD and Q\u2010SRP at 6 months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Although GCF NTx total amounts increased in all groups during the study period, this increase was less prominent in full\u2010mouth groups at three time points after treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Present results represent the short\u2010term effects. Full\u2010mouth treatment approaches offered limited beneficial effects on microbiological and biochemical parameters over quadrant\u2010wise approach. All three treatment strategies can be recommended in the management of severe chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0445","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T18:54:22Z","timestamp":1580928862000},"page":"638-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Full\u2010mouth disinfection effects on gingival fluid calprotectin, osteocalcin, and N\u2010telopeptide of Type I collagen in severe periodontitis"],"prefix":"10.1002","volume":"91","author":[{"given":"Beral","family":"Afacan","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhat","family":"\u00c7\u0131narc\u0131k","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ege 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