{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:53:29Z","timestamp":1784728409130,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aim of the present study was to ascertain if a combination of leukocyte and platelet\u2010rich fibrin (L\u2010PRF) + autogenous bone graft (ABG) may be a clinically \u201cnon\u2010inferior\u201d treatment modality as compared with the association of enamel matrix derivative (EMD) with ABG in the management of intrabony defects (IBDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of forty\u2010four patients, exhibiting at least one unfavorable intraosseous defect, were treated by L\u2010PRF associated with ABG (22 patients; test group) or EMD+ABG (control group) in each defect. At baseline and 12 months, a complete clinical and radiographic examination was done. Pre\u2010 and post\u2010therapy clinical (probing pocket depth [PPD], clinical attachment level [CAL], gingival recession [GR]) and radiographic (defect Bone level [(DBL)] parameters for the different treatments were compared. To guarantee the test treatment's efficacy 1mm was chosen as non\u2010inferiority margin; for clinical relevance, a second non\u2010inferiority margin = 0.5 mm was set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical and radiographic parameters significantly improved 12 months after surgery in both test and control sites, without inter\u2010groups differences for each measurement. The control group \u2013 test group differences for the parameters CAL gain \u22120.248 mm (\u22120.618 to 0.122), PPD Reduction \u22120.397 mm (\u22120.810 to 0.015), GR Change 0.059 mm (\u22120.300 to 0.418), DBL\u00a0Gain \u22120.250 mm\u00a0(\u22120.746 to 0.246) were all within the non\u2010inferiority margin of 0.5 mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the L\u2010PRF+ABG combined treatment of non\u2010contained IBDs produces non\u2010inferior results in terms of CAL gain, PPD reduction, GR increase and DBL gain in comparison with the EMD+ABG combination.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0533","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T14:25:10Z","timestamp":1586960710000},"page":"1595-1608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Periodontal regeneration by leukocyte and platelet\u2010rich fibrin with autogenous bone graft versus enamel matrix derivative with autogenous bone graft in the treatment of periodontal intrabony defects: A randomized non\u2010inferiority trial"],"prefix":"10.1002","volume":"91","author":[{"given":"Michele","family":"Paolantonio","sequence":"first","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Di Tullio","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Giraudi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences C.I.R. Dental School University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Secondi","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Paolantonio","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Graziani","sequence":"additional","affiliation":[{"name":"Department of Surgical Medical and Molecular Pathology and Critical Care Medicine Sub\u2010Unit of Periodontology Halitosis and Periodontal Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pilloni","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Section of Periodontics Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"De Ninis","sequence":"additional","affiliation":[{"name":"\u201cLuisa D'Annunzio\" Institute for High Culture  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Femminella","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.12.1485"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.130685"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1491-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12117"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800624391"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2012.55.11.403"},{"key":"e_1_2_7_8_1","unstructured":"The CONSORT Group. CONSORT. Available at:http:\/\/www.consort-statement.org\/. Accessed May 2 2013."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500605"},{"key":"e_1_2_7_10_1","first-page":"628","article-title":"Committee for medical products for human HSE; efficacy working party; committee for release for consultation. committee for medical products for humane use: guideline on the choice of the non\u2010inferiority margin. European Medicines Agency","volume":"25","year":"2006","journal-title":"Stat Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_7_13_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.10.934"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3138"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01815.x"},{"key":"e_1_2_7_17_1","unstructured":"US food and drug administration.Non\u2010inferiority clinical trials to establish effectiveness guidance for industry. U.S. department of health and human services food and drug administration center for drug evaluation and research (CDER) center for biologics evaluation and research (CBER)November2016 Washington DC."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1783"},{"key":"e_1_2_7_19_1","first-page":"55","article-title":"PRF: an opportunity in perio\u2010implantology","volume":"42","author":"Choukroun J","year":"2000","journal-title":"Implantodontie"},{"key":"e_1_2_7_20_1","first-page":"589","article-title":"The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures","volume":"19","author":"Cortellini P","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00865.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01446.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12598"},{"key":"e_1_2_7_24_1","first-page":"86","article-title":"Efficacy of platelet\u2010rich fibrin vs. enamel matrix derivative in the treatment of periodontal intrabony defects: a clinical and cone beam computed tomography study","volume":"16","author":"Gupta SJ","year":"2014","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.189753"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.1.31"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.01607.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00250.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601610010174"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1991-7902(09)60018-0"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.281113.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290110.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2209\/tdcpublication.2017-0021"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01844.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33262"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1971.42.10.648"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290407.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01263.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.12.719"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2900"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2133-z"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12643"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110722"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1973.44.4.194"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb01380.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1975.46.9.515"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.7.333"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00252.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.19-0533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.19-0533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JPER.19-0533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.19-0533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:08:28Z","timestamp":1760868508000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.19-0533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/JPER.19-0533"],"URL":"https:\/\/doi.org\/10.1002\/jper.19-0533","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,17]]},"assertion":[{"value":"2019-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}