{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:38:14Z","timestamp":1790116694033,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["17\u2010125"],"award-info":[{"award-number":["17\u2010125"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>MicroRNAs (miRNAs) are small noncoding RNAs demonstrated as critical post\u2010transcriptional modulators in dental tissues and bone regeneration, particularly miR\u201021\u20105p. However, the role of miR\u201021\u20105p in the healing of alveolar sockets following tooth extraction remains unknown. In this study we evaluated the influence of miR\u201021\u20105p in the healing of alveolar socket after tooth extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight miR\u201021\u20105p knockout mice and eight littermate controls underwent tooth extraction of the upper right incisor. After a healing period of 14 days microCT and histological analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MicroCT analysis showed that the percentage of bone in the extraction socket was significantly higher in the control group than in the miR\u201021 knockout mice; either in the coronal (39.0%, CI 31.8 to 48.0 versus 23.0%, CI 17.8 to 35.2, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) or in the middle part of the alveolar socket (56.0%, CI 50.9 to 62.5 versus 43.5% CI 28.6 to 54.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). These differences were not noted in the apical part of the extraction socket. Histological analysis supported the microCT findings. Newly bone volume per tissue volume (BV\/TV) was significantly higher in the control group when compared to miR\u201021 knockout mice, 27.4% (CI 20.6 to 32.9) versus 19.0% (CI 14.7 to 21.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), respectively. Surprisingly, no evident signs of buccal bone resorption were observed in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the limitation of one observation period, these findings suggest that miR\u201021\u20105p delays the early healing of alveolar socket following tooth extraction. Whether miR\u201021\u20105p is essential for healing of alveolar sockets remains to be elucidated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0567","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T13:21:44Z","timestamp":1589289704000},"page":"1664-1672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["miRNA\u201021 deficiency impairs alveolar socket healing in mice"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-7327","authenticated-orcid":false,"given":"Franz Josef","family":"Strauss","sequence":"first","affiliation":[{"name":"Department of Oral Biology Medical University of Vienna  Vienna Vienna Austria"},{"name":"Department of Conservative Dentistry School of Dentistry University of Chile  Santiago Chile"},{"name":"Clinic of Reconstructive Dentistry Center of Dental Medicine University of Zurich  Zurich 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