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The rationale for this decision was the lack of specific patterns of immune\u2010inflammatory response or microbial profiles associated with CP or AgP. However, no previous studies have compiled the results of all studies comparing subgingival microbial data between these clinical conditions. Thus, this systematic review aimed to answer the following focused question: \u201cDo patients with AgP periodontitis present differences in the subgingival microbiota when compared with patients with CP?\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted according to the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to June 2019 for studies of any design (except case reports, case series, and reviews) comparing subgingival microbial data from patients with CP and AgP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 488 articles were identified and 56 were included. Thirteen studies found <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> elevated in AgP in comparison with CP, while <jats:italic>Fusobacterium nucleatum, Parvimonas micra<\/jats:italic>, and <jats:italic>Campylobacter rectus<\/jats:italic> were elevated in AgP in a few studies. None of these species were elevated in CP. However, the number of studies not showing statistically significant differences between CP and AgP was always higher than that of studies showing differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggested an association of <jats:italic>A. actinomycetemcomitans<\/jats:italic> with AgP, but neither this species nor the other species studied to date were unique to or could differentiate between CP and AgP (PROSPERO #CRD42016039385).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0586","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T12:53:32Z","timestamp":1585659212000},"page":"1503-1520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Do patients with aggressive and chronic periodontitis exhibit specific differences in the subgingival microbial composition? 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