{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:46:10Z","timestamp":1790214370222,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the frequency of systemic drugs taken by elderly patients with or without periodontitis and the possible association between medication consumption and the severity of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1221 patients, including 608 with generalized moderate to severe periodontitis (periodontitis group) and 613 age\u2010 and gender\u2010matched individuals with healthy periodontium (healthy group) were selected. Systemic conditions, medications and periodontal status were recorded. Medication intake frequency (%) was compared using unconditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The top three most common medications were angiotensin\u2010converting enzyme (ACE) inhibitors (17.9%), antidepressants (17.8%), and lipid\u2010lowering medications (16.5%). Both ACE inhibitors and antidepressants showed statistically higher intake frequency in the periodontitis group relative to healthy controls (21.5%\u00a0versus 14.4%; odds ratio [OR]\u00a0=\u00a01.64), (21.1%\u00a0versus 14.5%, OR\u00a0=\u00a01.57) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Additionally, intake of oral hypoglycemic agents, calcium channel blockers (CCB), insulin, and diuretics were significantly higher in the periodontitis group with OR\u00a0=\u00a02.49, 2.32, 2.08 and 1.79, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Several medications demonstrated a disease severity\u2010dependent association comparing generalized severe periodontitis with moderate periodontitis and healthy group: oral hypoglycemic agents (17.4%\u00a0versus 16.8%\u00a0versus 8.0%), CCB (14.8%\u00a0versus 14.4%\u00a0versus 8.0%) and anticonvulsants (13.4%\u00a0versus 7.7%\u00a0versus 6.4%) with OR of 2.43, 1.99, and 2.28 (severe periodontitis versus healthy group), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a significantly higher frequency of medication intake related to cardiovascular disease and diabetes in patients with periodontitis. A disease severity\u2010dependence with medication intake frequency was also noted. This study provides indirect evidence for the possible relationship between systemic diseases and periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0593","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T07:45:44Z","timestamp":1582184744000},"page":"1245-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between periodontitis and systemic medication intake: A case\u2010control study"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-2038","authenticated-orcid":false,"given":"I\u2010Ching","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Periodontics University of Michigan  Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houssam","family":"Askar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontics University of Michigan  Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iya","family":"Ghassib","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontics University of Michigan  Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-4121","authenticated-orcid":false,"given":"Chin\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontics University of Michigan  Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontics University of Michigan  Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12947"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12534"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12089"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12808"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150088"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13154"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00327"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150597"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12982"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519846113"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.157001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/768237"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.04.030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050233"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000-1967-099"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0224"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000601"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1424"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/2141-9248.139311"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110748"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.2.123"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.300304.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.1.76"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00176-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22051"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.01.006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13039"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12036"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.7507"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.00347"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27304"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001059"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12291"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60733-3"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1995.tb00263.x"},{"key":"e_1_2_8_40_1","first-page":"5","article-title":"Oral health and treatment needs in institutionalized psychiatric patients in India","volume":"11","author":"Kenkre AM","year":"2000","journal-title":"Indian J Dent Res"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2012.00558.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016359509005942"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.48.3.d"},{"key":"e_1_2_8_44_1","first-page":"233","article-title":"Five\u2010year follow\u2010up of oral health and seizure condition of patients with epilepsy: a prospective observational study","volume":"27","author":"Karolyhazy K","year":"2010","journal-title":"Community Dent Health"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2013.12.008"},{"key":"e_1_2_8_46_1","first-page":"b140","article-title":"The effects of antiepileptic drugs on oral health","volume":"77","author":"Cornacchio AL","year":"2011","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb01377.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40780-017-0088-5"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00454.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160384"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050280"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090628"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12380"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070648"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12553"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.023"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.19-0593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.19-0593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JPER.19-0593","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.19-0593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:50:52Z","timestamp":1760863852000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.19-0593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/JPER.19-0593"],"URL":"https:\/\/doi.org\/10.1002\/jper.19-0593","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,5]]},"assertion":[{"value":"2019-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}