{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:40:28Z","timestamp":1760870428522,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A pilot randomized controlled clinical trial was performed to evaluate the efficacy of a post\u2010foaming dental gel containing cetylpridinium chloride (CPC), hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), sodium bicarbonate, and antioxidants on periodontal\/oral health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals with gingivitis or mild\u2010moderate periodontitis (<jats:italic>n<\/jats:italic>=36) were included and randomly assigned to Group 1 and 2 with foaming gel loaded on a mouthpiece with a light source and controlled warming heat built\u2010in unit or on a toothbrush, respectively, in addition to regular twice\u2010daily brushing. Group 3 served as control with twice daily brushing and further assigned split\u2010mouth to Group 3a\u2010un\u2010flossed and Group 3b\u2010flossed. Gingival index (GI) and bleeding on probing (BOP) were evaluated in addition to plaque index (PI), pocket depth, and clinical attachment level at days 14, 28, 42 (treatment), and 60 (maintenance). Subgingival plaque microbial profiles and gingival crevicular fluid (GCF) cytokine levels were determined by DNA\u2010DNA hybridization and multiplexing assays, respectively. Exploratory analyses included esthetic outcomes: changes in tooth color and levels of volatile sulfur compounds in breath. Statistical analyses were conducted using ANOVA with a post hoc analysis of Fisher's LSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Use of post\u2010foaming gel in both test groups resulted in significant changes in GI and BOP at Day 42 compared to control and un\u2010flossed control (<jats:italic>P<\/jats:italic>&lt;0.05). Device\u2010enhanced foaming gel significantly reduced the PI in Group 1 at Day 42 compared to control and un\u2010flossed control (<jats:italic>P<\/jats:italic>=0.02; <jats:italic>P<\/jats:italic>=0.007, respectively). GCF IL\u20106 and TNF\u2010\u03b1 levels were significantly reduced in Group 2 compared to control (<jats:italic>P<\/jats:italic><jats:sub>IL\u20106<\/jats:sub>=0.01, <jats:italic>P<\/jats:italic><jats:sub>TNF\u2010\u03b1<\/jats:sub>=0.02). Post\u2010foaming gel resulted in greater reductions in periodontopathogens, whereas health\u2010associated species remained stable. Despite cessation of adjunct treatments, Group 1 and 2 continued having reduced levels of GI, BOP, and PI at Day 60 (<jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel post\u2010foaming dental gel improves oral health by reducing gingival inflammation at the local site in addition to better esthetic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0594","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T04:08:51Z","timestamp":1588738131000},"page":"1569-1583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of a novel post\u2010foaming dental gel on gingival inflammation: A randomized controlled clinical trial"],"prefix":"10.1002","volume":"91","author":[{"given":"Jonathan B.","family":"Levine","sequence":"first","affiliation":[{"name":"GLO Science, Inc.  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Goncalves","sequence":"additional","affiliation":[{"name":"GLO Science, Inc.  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research The Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research The Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Hasturk","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research The Forsyth Institute  Cambridge Massachusetts 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