{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:50:47Z","timestamp":1791438647438,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare the histologic difference in healing between ridge preservation sites treated with a combination allograft of 70% mineralized and 30% demineralized freeze\u2010dried bone allograft (FDBA) evaluated at 8 to 10\u00a0weeks versus 18 to 20\u00a0weeks post\u2010extraction. Changes in morphological ridge dimensions were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four patients with a single\u2010rooted tooth to be extracted and replaced by a dental implant were recruited for this study. At time of extraction, measurements were taken with a custom acrylic stent, and the extraction socket was grafted with the combination allograft and covered with a nonresorbable membrane. Patients were randomly assigned to the short\u2010term (8 to 10\u00a0weeks) or long\u2010term (18 to 20\u00a0weeks) healing group. Sites were re\u2010entered for study measurements, a bone core sample, and implant placement. Bone cores obtained during implant placement were analyzed histologically to determine percentages of vital bone, residual graft, and CT\/other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight of the 44 patients completed the study, 19 in each group. There was a significant difference between the two groups for mean percent vital bone formation (short\u2010term\u00a0=\u00a018.17%, long\u2010term\u00a0=\u00a040.32%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;\u00a00.0001) and percentage of residual graft (short\u2010term\u00a0=\u00a041.54%, long\u2010term\u00a0=\u00a023.59%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;\u00a00.0001). There was no difference in morphological changes between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ridge preservation using combination FDBA resulted in approximately twice as much vital bone and half as much residual graft material after 18 to 20\u00a0weeks of healing compared to only 8 to 10\u00a0weeks healing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0610","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T01:13:38Z","timestamp":1581556418000},"page":"1256-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A randomized controlled trial on the impact of healing time on wound healing following ridge preservation using a 70%\/30% combination of mineralized and demineralized freeze\u2010dried bone allograft"],"prefix":"10.1002","volume":"91","author":[{"given":"Aaron C.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Periodontics UT Health San Antonio  San Antonio TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Mealey","sequence":"additional","affiliation":[{"name":"Department of Periodontics UT Health San Antonio  San Antonio TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01482.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513506713"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514541127"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5263"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"e2","article-title":"Alveolar ridge preservation after tooth extraction using different bone graft material and autologous platelet concentrate: a systematic review","volume":"10","author":"Strumbras A","year":"2019","journal-title":"J Oral Maxillofac Res"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.7.990"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13057"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00148.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.11.1085"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)85915-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110270"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160139"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140483"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130178"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110209"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170155"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0199"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100286"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2913"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJPER.19-0610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.19-0610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JPER.19-0610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.19-0610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:50:47Z","timestamp":1760863847000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.19-0610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/JPER.19-0610"],"URL":"https:\/\/doi.org\/10.1002\/jper.19-0610","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,3]]},"assertion":[{"value":"2019-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}