{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:50:44Z","timestamp":1793508644196,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Supplementation with omega\u20103 polyunsaturated fatty acids (\u03c9\u20103 PUFA) and low\u2010dose aspirin (ASA) have been proposed as a host modulation regimen to control chronic inflammatory diseases. The aim of this study was to investigate the clinical and immunological impact of orally administered \u03c9\u20103 PUFA and ASA as adjuncts to periodontal debridement for the treatment of periodontitis in patients type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five patients (n\u00a0=\u00a025\/group) were randomly assigned to receive placebo and periodontal debridement (CG), \u03c9\u20103 PUFA + ASA (3\u00a0g of fish oil\/d + 100\u00a0mg ASA\/d for 2 months) <jats:italic>after<\/jats:italic> periodontal debridement (test group [TG]1), or \u03c9\u20103 PUFA + ASA (3\u00a0g of fish oil\/d + 100\u00a0mg ASA\/d for 2 months) <jats:italic>before<\/jats:italic> periodontal debridement (TG2). Periodontal parameters and GCF were collected at baseline (t0), 3 months after periodontal debridement and \u03c9\u20103 PUFA + ASA or placebo for TG1 and CG (t1), after \u03c9\u20103 PUFA + ASA (before periodontal debridement) for TG2 (t1), and 6 months after periodontal debridement (all groups) (t2). GCF was analyzed for cytokine levels by multiplex ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients (40%) in TG1 and nine patients (36%) in TG2 achieved the clinical endpoint for treatment (less than or equal to four sites with probing depth \u2265 5\u00a0mm), as opposed to four (16%) in CG. There was clinical attachment gain in moderate and deep pockets for TG1. IFN\u2010\u03b3 and interleukin (IL)\u20108 levels decreased over time for both test groups. IL\u20106 levels were lower for TG1. HbA1c levels reduced for TG1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjunctive \u03c9\u20103 and ASA after periodontal debridement provides clinical and immunological benefits to the treatment of periodontitis in patients with type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0613","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T23:46:33Z","timestamp":1582760793000},"page":"1318-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Omega\u20103 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial"],"prefix":"10.1002","volume":"91","author":[{"given":"Nidia C.","family":"Castro dos Santos","sequence":"first","affiliation":[{"name":"Division of Periodontics Unesp \u2013 S\u00e3o Paulo State University, Institute of Science and Technology  S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"},{"name":"Center for Clinical and Translational Research The Forsyth Institute  Cambridge MA USA"},{"name":"Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naira M. 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