{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:38:28Z","timestamp":1776789508370,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Association between periodontitis and prostate diseases of benign prostatic hyperplasia (BPH) and prostatitis is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the National Health Insurance Research Database of Taiwan, 5,510 patients with newly diagnosed chronic periodontitis and participated in therapies were selected from 2000 to 2015 as cohort 1. Matched with age and index year, 5,510 patients with periodontitis diagnosis without therapy were selected as cohort 2, and 5,510 participants without diagnosis were used as control. Cox proportional hazard and survival analysis were performed to compare the risks and the survival probabilities among cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In two periodontitis cohorts, 636 and 638 participants compared with 550 in control (1,174 and 1,187\u00a0versus 989 per 100,000 person\u2010years) had prostate disorder. Difference was identified for prostatitis (n\u00a0=\u00a068, 70\u00a0versus 34; rate\u00a0=\u00a0125, 130\u00a0versus 61 \/100,000 person\u2010years; <jats:italic>P\u00a0<\/jats:italic>&lt;0.001) but not for BPH (n\u00a0=\u00a0577, 575, versus 529; rate\u00a0=\u00a01,065, 1,070\u00a0versus 951 \/100,000 person\u2010years, respectively). Different survival probabilities for prostate disorder and prostatitis, but not for BPH, were observed among cohorts. Periodontitis patients were more likely to develop prostate disorder after adjustment (adjusted hazard ratio [aHR] of 2.590 to 2.641 by competing model). With stratification, risks between two periodontitis cohorts exhibited no difference. When BPH cases were excluded, the aHRs for prostatitis were 4.611 to 4.798.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite treatment, the patients with periodontitis had higher risk of developing prostatitis than patients without periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.19-0706","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T06:45:36Z","timestamp":1594017936000},"page":"72-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of chronic periodontitis with prostatic hyperplasia and prostatitis: A population\u2010based cohort study in Taiwan"],"prefix":"10.1002","volume":"92","author":[{"given":"Earl","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Dentistry Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation  New Taipei City Xindian Taiwan, ROC"},{"name":"Department of Dentistry Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Mao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dentistry Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation  New Taipei City Xindian Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medical Research Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan, ROC"},{"name":"School of Public Health National Defense Medical Center  Taipei ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Cheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dentistry Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Tri\u2010Service General Hospital  Taipei Taiwan, ROC"},{"name":"School of Medicine National Defense Medical Center  Taipei Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Huan","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Medical Research Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan, ROC"},{"name":"School of Public Health National Defense Medical Center  Taipei ROC"},{"name":"Graduate Institute of Life Sciences National Defense Medical Center  Taipei Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00034-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.3.236"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"1","article-title":"Benign prostatic hyperplasia: epidemiology, economics and evaluation","volume":"22","author":"Vuichoud C","year":"2015","journal-title":"Can J Urol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090646"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_746_18"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160477"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.11.015"},{"key":"e_1_2_8_9_1","unstructured":"National Health Insurance Research Database. 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