{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:56:54Z","timestamp":1787759814934,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peri\u2010implant disease (PID) has not been directly linked to pathological organ changes. The present study assessed the dynamics of serum biochemical parameters in a model of experimental peri\u2010implantitis in dogs, followed by open flap debridement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven male beagle dogs comprised the study group. Procedures were performed as follows\u2014extractions of two premolars and one molar on each mandibular quadrant (Day 0); bone healing time (week14); placement of four rough\u2010surface endoosseous implants, two on each mandibular side; implant uncovering (week 28); induction of experimental peri\u2010implantitis by the use of three ligatures (weeks 31, 34, 37) followed by open flap debridement (week 42). Serum biochemical analysis following each procedure was compared to baseline. Biochemical parameters were assigned into four subsets of variables\u2014inflammation, renal function, liver function, and blood glucose. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following experimental peri\u2010implantitis, the dynamics of renal parameters and blood glucose were minimal whereas statistically significant (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) increases were noted for inflammatory (total protein and albumin concentrations) and hepatic (ALT, AST) parameters. A statistically significant (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) decrease was only noted for total bilirubin. After open flap debridement, inflammatory (total protein and albumin concentrations) and hepatic (AST) parameters returned to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within their limits, the present results indicate that: (a) PID affects inflammatory and hepatic serum biochemical parameters, and (b) following open flap debridement most of the values returned to baseline.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0048","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T19:25:49Z","timestamp":1597087549000},"page":"436-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of peri\u2010implant infection on serum biochemical analysis"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-7526","authenticated-orcid":false,"given":"Liat","family":"Chaushu","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Tal","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Fern\u00e1ndez\u2010Tom\u00e9","sequence":"additional","affiliation":[{"name":"Laparoscopy Unit Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre  Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center\u2014Beilinson Hospital  Petach Tikva Israel"},{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12953"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12369"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000841"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000873"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000876"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000874"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.09.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12562"},{"issue":"7","key":"e_1_2_9_11_1","first-page":"103","article-title":"The effect of chronic periodontitis on the development of atherosclerosis: review of the literature","volume":"14","author":"Niedzielska I","year":"2008","journal-title":"Med Sci Monit"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.12.022"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00641.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01288.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101535"},{"issue":"5","key":"e_1_2_9_16_1","first-page":"255","article-title":"Periodontal disease as a risk factor in pregnancy","volume":"54","author":"Felice","year":"2005","journal-title":"Minerva Stomatol"},{"issue":"4","key":"e_1_2_9_17_1","first-page":"107","article-title":"Periodontal disease and diabetes mellitus. 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