{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:39:33Z","timestamp":1793572773964,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aim of the pilot study was the histologic classification of the inflamed peri\u2010implant soft tissue around ceramic implants (CI) in comparison with titanium implants (TI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peri\u2010implant tissue were retrieved from 15 patients (aged 34 to 88 years, seven males\/eight females) with severe peri\u2010implantitis (eight CI, seven TI). The peri\u2010implant soft tissue samples were retrieved from the sites during scheduled removal of the implant and prepared for immunohistochemical analysis. Monoclonal antibodies (targeting CD3, CD20, CD138, and CD68) were used to identify T\u2010 and B\u2010cells, plasma cells and macrophages. Quantitative assessment was performed by one histologically trained investigator. Linear mixed regression models were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A similar numerical distribution of the cell population was found in peri\u2010implantitis around CI compared with TI. CD3 (TI, 17% to 85%\u00a0versus CI, 20% to 70% of total cell number) and CD138 (TI, 1% to 73% versus CI, 12% to 69% of total cell number) were predominantly expressed. Notably, patient\u2010individual differences of numerical cell distribution were detected. Co\u2010localization of B\u2010 and T\u2010lymphocytes was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peri\u2010implantitis around CI in comparison with TI seems to have a similar histological appearance. Differences in cellular composition of peri\u2010implantitis lesions might also depend on the patient's specific immune status and not only on the material used.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0169","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T03:42:55Z","timestamp":1598326975000},"page":"571-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Immunohistological composition of peri\u2010implantitis affected tissue around ceramic implants\u2014A pilot study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-7610","authenticated-orcid":false,"given":"Tobias","family":"Fretwurst","sequence":"first","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery Translational Implantology Center for Dental Medicine University Medical Center  Freiburg Baden\u2010W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery Translational Implantology Center for Dental Medicine University Medical Center  Freiburg Baden\u2010W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Odontology Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bronsert","sequence":"additional","affiliation":[{"name":"Institute of Surgical Pathology University Medical Center Freiburg, Germany, Tumorbank Comprehensive Cancer Center Freiburg, Medical Center\u2010 University of Freiburg, Freiburg, Germany, Faculty of Medicine University of Freiburg  Freiburg Baden\u2010W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Hazard","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center University of Freiburg  Freiburg Baden\u2010W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogerio M.","family":"Castilho","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Laboratory of Epithelial Biology Department of Periodontics and Oral Medicine University of Michigan School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Kohal","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry Center for Dental Medicine University Medical Center Freiburg  Freiburg Baden\u2010W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery Translational Implantology Center for Dental Medicine University Medical Center  Freiburg Baden\u2010W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Iglhaut","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery Translational Implantology Center for Dental Medicine University Medical Center  Freiburg Baden\u2010W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02547.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.10.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2276-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4386"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12718"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12274"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517740560"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.09.017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514551754"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13156"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13568"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516664043"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma8030932"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12842"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12815"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12180"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2015.10.008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160245"},{"key":"e_1_2_8_22_1","first-page":"e49","article-title":"EQUATOR: reporting guidelines for health research","volume":"2","author":"Altman DG","year":"2008","journal-title":"Open Med"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2000.011S1146.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12954"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3795"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-761643"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.980"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140559"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2018.4.e"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.03.042"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.06.027"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140363"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13305"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12469"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-018-0124-8"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.20-0169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JPER.20-0169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.20-0169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:02:15Z","timestamp":1760871735000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.20-0169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,17]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/JPER.20-0169"],"URL":"https:\/\/doi.org\/10.1002\/jper.20-0169","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,17]]},"assertion":[{"value":"2020-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}