{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:32:20Z","timestamp":1790188340124,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this prospective study is to evaluate the clinical applicability of the entire papilla preservation (EPP) technique in the regenerative treatment of isolated deep intrabony defects using native collagen membrane and bone grafting materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen healthy and non\u2010smoker patients (nine males and six females; mean age: 47.73 \u00b1 12.18; range 21 to 63 years) with one isolated deep intrabony defect each (baseline probing depth (PD): 9.03 \u00b1 1.62\u00a0mm; clinical attachment level (CAL): 11.16 \u00b1 1.81\u00a0mm) were treated with guided tissue regeneration. Surgical access to the defect was provided by a single buccal vertical incision with an interdental tunneling flap. Following the granulation tissue removal, intrabony defect was filled with bone substitutes. A collagen barrier was trimmed and placed under the intact defect\u2010associated papilla with palatal positioning suture. Microsurgical sutures were used for primary closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1\u00a0week, healing of the 15 sites was uneventful. During the study, all sites showed 100% primary closure rate. At 1\u2010year follow\u2010up, an average CAL gain of 5.86 \u00b1 1.28\u00a0mm (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), PD reduction of 6.1 \u00b1 1.47\u00a0mm (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), and minimal increase in gingival recession of 0.23 \u00b1 0.62\u00a0mm (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.168) were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This novel surgical technique, that keeps the interdental papilla intact, seems promising to provide optimal biomaterial protection and healing conditions, even when a collagen barrier and bone substitutes are applied.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0288","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T11:20:35Z","timestamp":1598008835000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Reconstructive surgical 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