{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:24:59Z","timestamp":1781803499181,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Growing evidence shows the efficacy of platelet concentrates in periodontal therapy. This study aimed to demonstrate that an inorganic bovine bone graft (IBB) in combination with a leukocyte and platelet rich fibrin (L\u2010PRF) is non\u2010inferior to a combination with a collagen membrane (CM) when managing unfavorable infrabony defects (IBDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients exhibited at least one unfavorable IBD; they were randomly assigned to two groups, 31 treated with L\u2010PRF+IBB and 31 with CM+IBB. A clinical and radiographic examination was performed at baseline and 12 months later. Clinical attachment level (CAL), gingival recession (GR), probing depth (PD), and radiographic defect bone level (DBL) post\u2010therapy changes were compared between the two treatments. A non\u2010inferiority margin\u00a0=\u00a01\u00a0mm was set to determine the efficacy of the test treatment (\u20121\u00a0mm for GR); a second non\u2010inferiority margin\u00a0=\u00a00.5\u00a0mm (\u20120.5\u00a0mm for GR) was chosen for clinical relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve months after surgery a significant improvement of clinical and radiographic parameters was observed at both experimental sites. The 90% confidence intervals of the CM+IBB\u2012L\u2010PRF+IBB mean difference for CAL gain (\u20120.810\u00a0mm [\u20121.300 to \u20120.319]) and DBL gain (\u20120.648\u00a0mm [\u20121.244 to \u20120.052]) were below the 0.5\u00a0mm non\u2010inferiority margin; GR increase (1.284\u00a0mm [0.764 to 1.804]) remained above the \u20120.5\u00a0mm, while PD reduction (0.499\u00a0mm [0.145 to 0.853]) crossed its 0.5\u2010mm margin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The L\u2010PRF+IBB treatment of unfavorable IBDs offers non\u2010inferior efficacy for CAL gain, showing less GR and more DBL gain too, while for PD reduction it is inferior to the CM+IBB treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0305","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T06:47:05Z","timestamp":1612594025000},"page":"1576-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of inorganic bovine bone combined with leukocyte and platelet\u2010rich fibrin or collagen membranes for treating unfavorable periodontal infrabony defects: Randomized non\u2010inferiority trial"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-0556","authenticated-orcid":false,"given":"Imena","family":"Rexhepi","sequence":"first","affiliation":[{"name":"Department of Innovative Technologies, in Medicine and Dentistry \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-6665","authenticated-orcid":false,"given":"Michele","family":"Paolantonio","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies, in Medicine and Dentistry \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies, in Medicine and Dentistry \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Serroni","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies, in Medicine and Dentistry \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies, in Medicine and Dentistry \u201cG. D'Annunzio\u201d University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Secondi","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Plastic and Reconstructive Surgery Tor Vergata University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Paolantonio","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies, in Medicine and Dentistry \u201cG. 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