{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:09:35Z","timestamp":1789639775180,"version":"4.0.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leucine\u2010rich alpha\u20102 glycoprotein (LRG) is a novel acute phase protein involved in inflammation\u2010associated diseases and that considered to be induced by multiple proinflammatory cytokines. This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)\u20106 and tumor necrosis factor (TNF)\u2010\u03b1 in patients with Stage 3 periodontitis before and after non\u2010surgical periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five Stage 3 periodontitis and twenty\u2010five periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non\u2010surgical periodontal treatment, and GCF and serum samples were obtained at baseline and at 6\u00a0weeks after treatment. LRG, IL\u20106 and TNF\u2010\u03b1 were determined by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GCF and serum LRG, IL\u20106 and TNF\u2010\u03b1 were significantly higher in periodontitis group than healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). A significant decrease in GCF and serum LRG, IL\u20106 and TNF\u2010\u03b1 was detected after periodontal treatment compared with baseline values of periodontitis patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings revealed that LRG expression was increased in Stage 3 periodontitis both locally and systemically, and non\u2010surgical periodontal therapy was effective in reducing LRG levels in GCF and serum of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0358","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T07:55:02Z","timestamp":1604130902000},"page":"104-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Leucine\u2010rich alpha\u20102 glycoprotein (LRG): A novel acute phase protein expressed in Stage 3 Grade C periodontitis before and after periodontal therapy"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-8752","authenticated-orcid":false,"given":"Zeynep Pinar","family":"Keles Yucel","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Giresun University  Giresun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut","family":"Balli","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Bulent Ecevit University  Zonguldak 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