{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:58:13Z","timestamp":1789750693530,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alveolar ridge preservation via socket grafting (ARP\u2010SG) is indicated to attenuate physiologic alveolar bone resorption as a consequence of tooth extraction. However, a specific bone grafting material that is patently superior has not been identified yet. The aim of this randomized controlled trial was to evaluate the efficacy of a moldable alloplastic graft, Poly Lactic\u2010Co\u2010Glycolic Acid\u2010Coated \u03b2\u2010Tricalcium Phosphate (PLGA\u2010\u03b2\u2010TCP), for ARP purposes [Group A] compared to freeze\u2010dried bone allograft (FDBA) particles covered with a rapidly absorbable collagen dressing (RACD) (Group B) in function of a panel of radiographic, histomorphometric, and implant\u2010related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients in need of extraction of a single posterior tooth (premolar or molar) and subsequent replacement with a dental implant were recruited and randomly allocated into one of the two treatment groups. Follow\u2010up visits took place at 1, 2, 4, 8, and 16\u00a0weeks. Cone\u2010beam Computed Tomography (CBCT) scans were obtained at baseline and at 16\u00a0weeks. Sites were re\u2010entered at 20\u00a0weeks for bone core biopsy harvesting and subsequent implant placement. After delivery of the final implant\u2010supported restoration, follow\u2010up visits were scheduled at 6 and 12 months to monitor peri\u2010implant tissue health and marginal bone levels using standardized intraoral periapical radiographs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 patients were initially enrolled in the study, of whom 43 received an implant and 32 completed the study. Healing was uneventful in all sites after ARP\u2010SG and implant placement. No site required bone augmentation to allow for implant placement. CBCT scan analyses showed no statistically significant differences between groups in terms of reduction of horizontal width, midbuccal \/ midlingual height and ridge volume. Histomorphometric assessments revealed a statistically significant difference between both groups in terms of mineralized tissue formation (Group A\u00a0=\u00a027.0% \u00b1 22.1%\u00a0versus Group B\u00a0=\u00a038.2% \u00b1 12.5%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). On the contrary, no significant differences were observed regarding percent of remaining bone grafting material and non\u2010mineralized tissue. No implant failed throughout the study period and marginal bone level change was negligible in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although a higher proportion of mineralized tissue was associated with the use of FDBA+RACD compared to PLGA\u2010\u03b2\u2010TCP alone, both ARP\u2010SG approaches rendered comparable outcomes in terms of maintenance of alveolar bone dimensions, feasibility of implant placement, implant survival, and peri\u2010implant bone level stability up to 12 months post\u2010loading.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0360","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:28:34Z","timestamp":1601425714000},"page":"524-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of poly lactic\u2010co\u2010glycolic acid\u2010coated \u03b2\u2010tricalcium phosphate for alveolar ridge preservation: A multicenter randomized controlled trial"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-1343","authenticated-orcid":false,"given":"Hanae","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Advanced Oral Sciences and Therapeutics, Division of Periodontics, School of Dentistry University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-4483","authenticated-orcid":false,"given":"Emilio","family":"Couso\u2010Queiruga","sequence":"additional","affiliation":[{"name":"Department of Periodontics, College of Dentistry University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan J.","family":"Shiau","sequence":"additional","affiliation":[{"name":"Department of Advanced Oral Sciences and Therapeutics, Division of Periodontics, School of Dentistry University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-2149","authenticated-orcid":false,"given":"Sandra","family":"Stuhr","sequence":"additional","affiliation":[{"name":"Department of Periodontics, College of Dentistry University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Prasad","sequence":"additional","affiliation":[{"name":"Hard Tissue Research Laboratory The University of Minnesota School of Dentistry  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trishul V.","family":"Allareddy","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Radiology and Medicine, College of Dentistry University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Advanced Oral Sciences 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