{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:46:19Z","timestamp":1790451979678,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010invasive methods for periodontitis diagnosis would be a clinically important tool. This cross\u2010sectional study aimed to investigate the association between oxidative stress, glycation, and inflammation markers and periodontal clinical parameters in periodontitis and periodontally healthy patients with type 2 diabetes and corresponding systemically healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven periodontally healthy (DM\u2010H, n\u00a0=\u00a032) and periodontitis (DM\u2010P, n\u00a0=\u00a035) patients with type 2 diabetes, and 54 systemically healthy periodontitis (H\u2010P, n\u00a0=\u00a026) and periodontally healthy (H\u2010H, n\u00a0=\u00a028) controls were included. Clinical periodontal parameters, body mass index, fasting glucose, hemoglobin A1c (HbA1c), along with saliva and serum 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG), malondialdehyde (MDA), 4\u2010hydroxy\u20102\u2010nonenal (4\u2010HNE), advanced glycation end products (AGE), AGE receptor (RAGE) and high sensitivity C\u2010reactive protein (hsCRP) levels were recorded and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Salivary 8\u2010OHdG levels were significantly higher in periodontitis compared to periodontally healthy patients, regardless of systemic status (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Salivary MDA levels were significantly higher in all disease groups compared to H\u2010H group (<jats:italic>P<\/jats:italic> \u2264 0.004). Serum AGE levels were significantly higher in diabetic groups than systemically healthy groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and in H\u2010<jats:italic>P<\/jats:italic> compared to H\u2010H (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Bleeding on probing (BOP) and clinical attachment level (CAL) strongly correlated with salivary 8\u2010OHdG and serum hsCRP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In systemically healthy patients, salivary 8\u2010OHdG was the most accurate marker to differentiate periodontitis from controls (AUC\u00a0=\u00a00.84). In diabetics salivary 4\u2010HNE and RAGE were the most accurate (AUC\u00a0=\u00a00.85 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary 8\u2010OHdG alone or in combination with 4\u2010HNE, AGE and RAGE for diabetics, and salivary 8\u2010OHdG alone or in combination with MDA and hsCRP for systemically healthy persons, could potentially serve as non\u2010invasive screening marker(s) of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0406","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T07:22:41Z","timestamp":1607152961000},"page":"1274-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Salivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross\u2010sectional 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