{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:44:48Z","timestamp":1788417888104,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the clinical, radiographic and patient\u2010centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty intrabony defects in AgP and CP patients associated with \u2265 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (\n                      <jats:italic>n<\/jats:italic>\n                      = 20); AgP+CS\/EMD (\n                      <jats:italic>n<\/jats:italic>\n                      = 20); CP+CS\/EMD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0 = \u00a020). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP\u201014 and VAS scale in the early post\u2010therapy period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PPD and relative clinical attachment level (rCAL) improved for all groups during follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 0.05), and AgP+CS\/EMD presented a higher rCAL gain (2.4 \u00b1 1.0 mm) when compared to AgP control patients (1.6 \u00b1 1.6 mm,\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 0.05) after 12 months. No difference was observed between AgP+CS\/EMD and CP+CS\/EMD groups (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05). No radiographic differences were observed among groups at any time point (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05). All the groups reported a positive impact on OHIP\u201014 total score, without differences among them.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.20-0493","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T04:45:55Z","timestamp":1603773955000},"page":"995-1006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical, radiographic, and patient\u2010centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12\u2010month multicenter clinical trial"],"prefix":"10.1002","volume":"92","author":[{"given":"Ana L\u00edvia","family":"Fileto Mazzonetto","sequence":"first","affiliation":[{"name":"Department of Prosthesis and Periodontology State University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5855","authenticated-orcid":false,"given":"Renato Corr\u00eaa Viana","family":"Casarin","sequence":"additional","affiliation":[{"name":"Department of Prosthesis and Periodontology State University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-0729","authenticated-orcid":false,"given":"Mauro Pedrine","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery State University of S\u00e3o Paulo  S\u00e3o Jos\u00e9 dos Campos 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University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enilson Antonio","family":"Sallum","sequence":"additional","affiliation":[{"name":"Department of Prosthesis and Periodontology State University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Wilson","family":"Sallum","sequence":"additional","affiliation":[{"name":"Department of Prosthesis and Periodontology State University of Campinas  Piracicaba 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