{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:11:02Z","timestamp":1780441862901,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Because of bisphosphonate medication, dental implantation with a subsequent infection poses a relevant risk factor to suffer from medication\u2010related osteonecrosis of the jaw. This rat study evaluated different implant materials under systemic bisphosphonate delivery using micro\u2010computed tomography (\u03bcCT) images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010four rats were randomly allocated into a control group 1, test group 2 with intravenous drug application of zoledronic acid and test group 3 with a subcutaneous application of alendronic acid. After 4 weeks of drug delivery, the first molar on each side of the upper jaw was extracted, and either a zirconia or a titanium implant was immediately inserted. Radiological examinations at four timepoints before the operation, 1 week later, 6 weeks later and after 12\u00a0weeks of follow up included \u03bcCT measurements of the in vivo peri\u2010implant bone loss. \u03bcCT measurements of the ex vivo peri\u2010implant bony structure after 12\u00a0weeks follow\u2010up covered the bone mineral density, \u2010volume, \u2010trabecular thickness and \u2010separation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both test groups showed a significant increase in bone loss over time (<jats:italic>P\u00a0&lt;\u00a00.05<\/jats:italic>). The clinical observations of exposed bone revealed that most cases occurred under alendronic acid delivery. Exposed bone was recorded only in the test groups around both titanium and zirconia implants. Regarding the peri\u2010implant bony structure, no significant differences were found between both materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic bisphosphonate delivery led to increased peri\u2010implant bone loss over time after immediate implant insertion. In terms of bone resorption and bone quality parameters, no implant material was superior to the other.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0547","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T02:02:20Z","timestamp":1606788140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Microstructural volumetric analysis of the jaw following dental implantation under systemic bisphosphonate delivery: An in vivo and ex vivo rat study"],"prefix":"10.1002","volume":"92","author":[{"given":"Kristian","family":"Kniha","sequence":"first","affiliation":[{"name":"Private clinic for oral and maxillofacial surgery, Kniha Schlegel and colleagues  Munich Germany"},{"name":"Department of Oral and Cranio\u2010Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna Anna","family":"Magnuska","sequence":"additional","affiliation":[{"name":"Department of Experimental Molecular Imaging RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Gremse","sequence":"additional","affiliation":[{"name":"Department of Experimental Molecular Imaging RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan Christian","family":"M\u00f6hlhenrich","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of Witten\/Herdecke  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"H\u00f6lzle","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Modabber","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillofacial Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2006.09.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.04.022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-015-0207-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.01.026"},{"key":"e_1_2_9_6_1","first-page":"21","article-title":"Definition of bone necrosis by the pathologist","volume":"4","author":"Fondi C","year":"2007","journal-title":"Clin Cases Miner Bone Metab"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1048392"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-018-0732-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-016-0041-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.037"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2017.07.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"2017 N Cionca D Hashim A Mombelli Zirconia dental implants: where are we now and where are we heading? 241 258","DOI":"10.1111\/prd.12180"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.10.013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2017.11.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.12766"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.10.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.10.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512472335"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.02.011"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.13624"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2723-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/93.3.491"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004586"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015020204"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.9293"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306294"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110069"},{"key":"e_1_2_9_29_1","volume-title":"Biology of the Laboratory Mouse","author":"Snell GD","year":"1941"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.394"},{"key":"e_1_2_9_31_1","first-page":"2265","article-title":"Influence of radiation exposure pattern on the bone injury and osteoclastogenesis in a rat model","volume":"44","author":"Zhai J","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13279-020-0269-8"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12571"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01677.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01125.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8670"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.070"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060390"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.1.107"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12355"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.20-0547","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JPER.20-0547","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JPER.20-0547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:21:24Z","timestamp":1760883684000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/JPER.20-0547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/JPER.20-0547"],"URL":"https:\/\/doi.org\/10.1002\/jper.20-0547","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,18]]},"assertion":[{"value":"2020-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}