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Regenerating interdental clinical attachment not only improves the prognosis of the tooth, but it also lessens the severity of the disease condition. This manuscript provides a state\u2010of\u2010the\u2010art review on surgical reconstructive approaches for treating papillary deficiency associated with soft and hard tissue interproximal defects. Combination therapy of papilla preservation, connective tissue grafting, and coronally advanced flaps may result in regeneration of the intrabony defect coupled with root coverage. Future research highlighted here may have the potential, especially in combination approaches, to repair challenging interproximal soft and hard tissue deficiencies.<\/jats:p>","DOI":"10.1002\/jper.20-0587","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T13:54:48Z","timestamp":1604584488000},"page":"931-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Interproximal attachment gain: The challenge of periodontal regeneration"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-147X","authenticated-orcid":false,"given":"Giulio","family":"Rasperini","sequence":"first","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan, Foundation IRCCS Ca\u2019 Granda Policlinic  Milan Italy"},{"name":"Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry  Ann Arbor MI 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