{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:01:15Z","timestamp":1768917675816,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007951","name":"Tokyo Medical and Dental University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Information regarding periodontal regenerative therapy in patients with diabetes mellitus (DM) is limited. This pilot study compared the regenerative outcomes of minimally invasive periodontal surgery using enamel matrix derivative (EMD) between DM and non\u2010DM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study included deep intrabony defects in patients with or without type 2 DM. Minimally invasive surgical technique (MIST) or modified MIST (M\u2010MIST) using EMD, without bone graft materials, was performed. Periodontal examination and intraoral radiography were performed at baseline, 6 months, and 1 and 3 years after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten sites of 10 subjects in the DM group, and 20 sites of 18 subjects in non\u2010DM group were evaluated (mean age; 67.5 \u00b1 7.6 and 63.1 \u00b1 9.7, respectively). Probing depth significantly decreased from 7.1 \u00b1 1.6 and 7.0 \u00b1 1.3\u00a0mm to 2.2 \u00b1 0.9 and 2.3 \u00b1 1.1\u00a0mm at the 1\u2010year examination in the DM and non\u2010DM groups, respectively. Clinical attachment level (CAL) gain and radiographical defect fill at the 3\u2010year examination were 3.8 \u00b1 1.1\u00a0mm and 58.3% \u00b1 10.4%, respectively, in the DM group, and 4.1 \u00b1 1.1\u00a0mm and 65.5% \u00b1 18.8%, respectively, in the non\u2010DM group, showing no significant differences between the groups. Multiple regression analysis showed no significant association of CAL gain with DM or age after adjustments for relevant confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first documented study of successful periodontal tissue regeneration in patients with DM. Minimally invasive surgery combined with EMD yielded significant clinical attachment gain and bone fill in the DM and non\u2010DM groups at comparable levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0590","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T21:15:10Z","timestamp":1607634910000},"page":"1262-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3\u2010year observation: A prospective cohort study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1610-7430","authenticated-orcid":false,"given":"Koji","family":"Mizutani","sequence":"first","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU)  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