{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:12:37Z","timestamp":1790273557969,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300914"],"award-info":[{"award-number":["81300914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis and orthodontic treatment can lead to inflammatory root resorption (IRR) through an unclear mechanism. Chemerin, a novel chemoattractant protein, is closely associated with inflammation, affects osteoblast and osteoclast differentiation, and may play a role in IRR. We aimed to explore possible roles of the chemerin\/ChemR23 interaction in cementoblast function and IRR and reveal a new IRR therapeutic target.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cementoblast function\u2010related gene and protein expression in the immortalized murine cementoblast cell line OCCM\u201030 after treatment with chemerin and siChemR23 was examined by qRT\u2010PCR and Western blotting. The roles of the MAPK and PI3K\u2010Akt signaling pathways were studied using specific inhibitors. Cementoblast cytokine production under different treatment conditions was measured by enzyme\u2010linked immunosorbent assay and qRT\u2010PCR. Additionally, we modeled IRR in wild\u2010type and chemerin\u2010overexpressing mice and injected transgenic mice with anti\u2010ChemR23 antibody to block ChemR23. We then calculated the root resorption volume and examined periodontal tissue cathepsin K, Runx2, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and interleukin\u20106 (IL\u20106) expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Chemerin suppressed cementoblast differentiation and mineralization and exerted a proinflammatory effect on cementoblasts. These effects were partially reversed by siChemR23 and reversed to different extents by p38, Erk1\/2 and PI3K\u2010Akt pathway inhibition, suggesting p38, Erk1\/2 and PI3K\u2010Akt pathways as signaling pathways downstream of chemerin\/ChemR23. In vivo, chemerin overexpression worsened IRR. Moreover, chemerin expression was positively correlated with TNF\u2010\u03b1, IL\u20106, and cathepsin K expression and negatively correlated with Runx2 expression. ChemR23 downregulation reversed these effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chemerin\/ChemR23 induced TNF\u2010\u03b1 and IL\u20106 expression dependent on Erk1\/2, p38 MAPK, and PI3K\u2010Akt signaling pathway activation, thereby regulating cementoblast function and affecting IRR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.20-0675","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T20:34:03Z","timestamp":1606854843000},"page":"1470-1482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chemerin\/ChemR23 regulates cementoblast function and tooth resorption in mice via inflammatory factors"],"prefix":"10.1002","volume":"92","author":[{"given":"Yusi","family":"Ye","sequence":"first","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing\u00a0Municipal\u00a0Key\u00a0Laboratory\u00a0of\u00a0Oral\u00a0Biomedical\u00a0Engineering\u00a0of\u00a0Higher\u00a0Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing\u00a0Municipal\u00a0Key\u00a0Laboratory\u00a0of\u00a0Oral\u00a0Biomedical\u00a0Engineering\u00a0of\u00a0Higher\u00a0Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing\u00a0Municipal\u00a0Key\u00a0Laboratory\u00a0of\u00a0Oral\u00a0Biomedical\u00a0Engineering\u00a0of\u00a0Higher\u00a0Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing\u00a0Municipal\u00a0Key\u00a0Laboratory\u00a0of\u00a0Oral\u00a0Biomedical\u00a0Engineering\u00a0of\u00a0Higher\u00a0Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing\u00a0Municipal\u00a0Key\u00a0Laboratory\u00a0of\u00a0Oral\u00a0Biomedical\u00a0Engineering\u00a0of\u00a0Higher\u00a0Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing\u00a0Municipal\u00a0Key\u00a0Laboratory\u00a0of\u00a0Oral\u00a0Biomedical\u00a0Engineering\u00a0of\u00a0Higher\u00a0Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.7.1027"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.11.1283"},{"key":"e_1_2_9_4_1","first-page":"161","article-title":"Hyalinization and root resorption during early orthodontic tooth movement in adolescents","volume":"68","author":"Kurol J","year":"1998","journal-title":"Angle Orthod"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.06.021"},{"key":"e_1_2_9_6_1","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. 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